|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:C-X-C_chemokine_receptor_type_7
gptkb:CXCR7
gptkb:Atypical_chemokine_receptor_3
|
|
gptkbp:associatedWith
|
HIV infection
inflammatory diseases
tumor metastasis
|
|
gptkbp:discoveredIn
|
2005
|
|
gptkbp:doesNotSignalVia
|
gptkb:G-protein
|
|
gptkbp:encodedBy
|
gptkb:ACKR3_gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000189057
57007
|
|
gptkbp:expressedIn
|
gptkb:kidney
brain
heart
endothelial cells
|
|
gptkbp:function
|
gptkb:scavenger_receptor
chemokine receptor
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
1816
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ACKR3
|
|
gptkbp:involvedIn
|
neural development
developmental processes
cardiovascular development
|
|
gptkbp:length
|
362
|
|
gptkbp:ligand
|
gptkb:CXCL11
gptkb:CXCL12
|
|
gptkbp:locatedOnChromosome
|
2q37.3
|
|
gptkbp:memberOf
|
gptkb:G_protein-coupled_receptor
gptkb:Atypical_chemokine_receptor_family
|
|
gptkbp:molecularWeight
|
40 kDa
|
|
gptkbp:OMIM
|
610425
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
|
|
gptkbp:PDB
|
gptkb:6KIL
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:regulates
|
CXCL12 availability
|
|
gptkbp:relatedTo
|
gptkb:CXCR4
|
|
gptkbp:role
|
angiogenesis
cancer progression
immune cell trafficking
|
|
gptkbp:signalsVia
|
beta-arrestin pathway
|
|
gptkbp:structureType
|
integral membrane protein
|
|
gptkbp:target
|
drug development
|
|
gptkbp:transmembraneDomains
|
7
|
|
gptkbp:UniProtID
|
P25106
|
|
gptkbp:bfsParent
|
gptkb:SDF-1
|
|
gptkbp:bfsLayer
|
7
|