|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:GPR159
CCX-CKR
CMKOR1
RDC1
|
|
gptkbp:alsoKnownAs
|
gptkb:C-X-C_chemokine_receptor_type_7
gptkb:CXCR7
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:cardiovascular_disease
inflammatory bowel disease
|
|
gptkbp:discoveredBy
|
2005
|
|
gptkbp:doesNotSignalVia
|
gptkb:G_proteins
|
|
gptkbp:encodes
|
gptkb:Atypical_chemokine_receptor_3
|
|
gptkbp:Entrez_Gene_ID
|
57007
|
|
gptkbp:expressedIn
|
gptkb:kidney
brain
heart
liver
lymphoid tissues
|
|
gptkbp:foundIn
|
vertebrates
|
|
gptkbp:function
|
regulates immune response
involved in cell migration
involved in tumor progression
involved in cardiovascular development
encodes a receptor for chemokines CXCL12 and CXCL11
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasTranscriptVariant
|
multiple
|
|
gptkbp:HGNC_ID
|
18147
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ACKR3 gene
|
|
gptkbp:length
|
362 amino acids
2,200 base pairs (approximate)
|
|
gptkbp:locatedOnChromosome
|
2q37.3
|
|
gptkbp:OMIM
|
610425
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Ackr3
|
|
gptkbp:proteinFamily
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:regulates
|
angiogenesis
neuronal development
inflammatory response
immune cell trafficking
cardiac development
endothelial cell function
CXCL11 signaling
CXCL12 signaling
stem cell migration
tumor cell metastasis
|
|
gptkbp:signalsVia
|
beta-arrestin pathway
|
|
gptkbp:UniProtID
|
P25106
|
|
gptkbp:bfsParent
|
gptkb:CXCR7
gptkb:ACKR3
|
|
gptkbp:bfsLayer
|
8
|