|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:ACE
gptkb:COVID-19
gptkb:AGT
gptkb:TMPRSS2
AGTR1
|
|
gptkbp:biologicalProcess
|
vasodilation
anti-inflammatory effects
carboxypeptidase
negative regulator of angiotensin II
protective role in lung injury
|
|
gptkbp:discoveredIn
|
2000
|
|
gptkbp:encodes
|
gptkb:Angiotensin-converting_enzyme_2
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000130234
59272
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
heart
intestine
|
|
gptkbp:fullName
|
Angiotensin I converting enzyme 2
|
|
gptkbp:function
|
regulation of blood pressure
catalyzes conversion of angiotensin II to angiotensin 1-7
|
|
gptkbp:HGNC_ID
|
HGNC:13557
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ACE2 gene
|
|
gptkbp:length
|
~40 kb
805 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:Xp22.2
X
|
|
gptkbp:mutationAssociatedWith
|
gptkb:cardiovascular_disease
gptkb:diabetes_mellitus
hypertension
COVID-19 severity
|
|
gptkbp:numberOfExons
|
18
|
|
gptkbp:OMIM
|
300335
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Ace2
|
|
gptkbp:pathway
|
gptkb:Renin-angiotensin_system
Peptide hormone metabolism
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
shedding by ADAM17
|
|
gptkbp:product
|
type I membrane protein
ACE2 protein
|
|
gptkbp:proteinFamily
|
transmembrane domain
cytoplasmic tail
collectrin domain
peptidase M2 domain
|
|
gptkbp:receptorFor
|
gptkb:SARS-CoV-2_spike_protein
gptkb:SARS-CoV_spike_protein
|
|
gptkbp:regulates
|
gptkb:androgens
gptkb:hypoxia
interferons
inflammatory cytokines
estrogens
|
|
gptkbp:symbol
|
gptkb:ACE2
|
|
gptkbp:UniProtID
|
gptkb:Q9BYF1
|
|
gptkbp:bfsParent
|
gptkb:Angiotensin-converting_enzyme_2
gptkb:angiotensin_I_converting_enzyme_2
|
|
gptkbp:bfsLayer
|
6
|