|
gptkbp:instanceOf
|
gptkb:virus
|
|
gptkbp:binds
|
gptkb:ACE2_receptor
|
|
gptkbp:cleavage
|
gptkb:furin
|
|
gptkbp:composedOf
|
gptkb:S1_subunit
gptkb:S2_subunit
|
|
gptkbp:contains
|
gptkb:receptor-binding_domain_(RBD)
fusion peptide
heptad repeat regions
|
|
gptkbp:enables
|
membrane fusion
|
|
gptkbp:encodedBy
|
gptkb:S_gene
|
|
gptkbp:foundIn
|
gptkb:COVID-19
|
|
gptkbp:function
|
mediates viral entry into host cells
|
|
gptkbp:glycosylation
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SARS-CoV-2 spike protein
|
|
gptkbp:length
|
1273 amino acids
|
|
gptkbp:mutationAssociatedWith
|
gptkb:D614G
gptkb:P681R
gptkb:E484K
gptkb:N501Y
|
|
gptkbp:orthologIn
|
gptkb:MERS-CoV_spike_protein
gptkb:SARS-CoV_spike_protein
|
|
gptkbp:structure
|
trimeric
|
|
gptkbp:subjectOf
|
vaccine development
immunology research
antibody escape studies
mutation tracking
structural biology studies
therapeutic design
|
|
gptkbp:surfaceProteinOf
|
gptkb:SARS-CoV-2_virion
|
|
gptkbp:target
|
gptkb:COVID-19_vaccines
antiviral drugs
neutralizing antibodies
convalescent plasma
monoclonal antibody therapies
|
|
gptkbp:usedIn
|
diagnostic tests
serological assays
|
|
gptkbp:variant
|
gptkb:Alpha_variant_spike_protein
gptkb:Delta_variant_spike_protein
gptkb:Omicron_variant_spike_protein
|
|
gptkbp:visualizes
|
cryo-electron microscopy
|
|
gptkbp:bfsParent
|
gptkb:CanSino_COVID-19_vaccine
gptkb:Novavax_COVID-19_vaccine
|
|
gptkbp:bfsLayer
|
5
|