Statements (50)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
biological pathway
|
| gptkbp:activatedBy |
low blood pressure
low sodium concentration |
| gptkbp:alsoKnownAs |
gptkb:RAS
|
| gptkbp:component |
gptkb:adrenal_gland
gptkb:angiotensin_receptors gptkb:juxtaglomerular_cells vascular smooth muscle |
| gptkbp:discoveredBy |
gptkb:Robert_Tigerstedt
|
| gptkbp:discoveredIn |
1898
|
| gptkbp:dysregulationAssociatedWith |
gptkb:primary_aldosteronism
congestive heart failure hypertension renal artery stenosis |
| gptkbp:effect |
water retention
vasoconstriction increased blood pressure sodium retention |
| https://www.w3.org/2000/01/rdf-schema#label |
Renin-angiotensin system
|
| gptkbp:influenced |
thirst
cardiac remodeling antidiuretic hormone release glomerular filtration rate salt appetite |
| gptkbp:inhibitedBy |
gptkb:angiotensin_receptor_blockers
ACE inhibitors |
| gptkbp:involves |
gptkb:renin
gptkb:angiotensin-converting_enzyme gptkb:angiotensin_I gptkb:angiotensin_II gptkb:aldosterone gptkb:angiotensinogen |
| gptkbp:location |
gptkb:kidney
lungs liver |
| gptkbp:regulates |
blood pressure
fluid balance electrolyte balance aldosterone secretion systemic vascular resistance sympathetic nervous system activity |
| gptkbp:relatedTo |
heart failure
hypertension chronic kidney disease |
| gptkbp:target |
adrenal cortex
antihypertensive drugs arterioles kidney tubules |
| gptkbp:bfsParent |
gptkb:ACE2
|
| gptkbp:bfsLayer |
5
|