|
gptkbp:instanceOf
|
gptkb:biological_pathway
|
|
gptkbp:activatedBy
|
low blood pressure
low sodium concentration
|
|
gptkbp:alsoKnownAs
|
gptkb:RAS
|
|
gptkbp:component
|
gptkb:adrenal_gland
gptkb:angiotensin_receptors
gptkb:juxtaglomerular_cells
vascular smooth muscle
|
|
gptkbp:discoveredBy
|
gptkb:Robert_Tigerstedt
|
|
gptkbp:discoveredIn
|
1898
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:primary_aldosteronism
congestive heart failure
hypertension
renal artery stenosis
|
|
gptkbp:effect
|
water retention
vasoconstriction
increased blood pressure
sodium retention
|
|
gptkbp:influenced
|
thirst
cardiac remodeling
antidiuretic hormone release
glomerular filtration rate
salt appetite
|
|
gptkbp:inhibitedBy
|
gptkb:angiotensin_receptor_blockers
ACE inhibitors
|
|
gptkbp:involves
|
gptkb:renin
gptkb:angiotensin-converting_enzyme
gptkb:angiotensin_I
gptkb:angiotensin_II
gptkb:aldosterone
gptkb:angiotensinogen
|
|
gptkbp:location
|
gptkb:kidney
lungs
liver
|
|
gptkbp:regulates
|
blood pressure
fluid balance
electrolyte balance
aldosterone secretion
systemic vascular resistance
sympathetic nervous system activity
|
|
gptkbp:relatedTo
|
heart failure
hypertension
chronic kidney disease
|
|
gptkbp:target
|
adrenal cortex
antihypertensive drugs
arterioles
kidney tubules
|
|
gptkbp:bfsParent
|
gptkb:ACE2
gptkb:ACE_gene
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Renin-angiotensin system
|