angiotensin I converting enzyme 2

URI: https://gptkb.org/entity/angiotensin_I_converting_enzyme_2
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alsoKnownAs gptkb:ACE2
gptkbp:cleavage gptkb:ADAM17
gptkbp:discoveredIn 2000
gptkbp:domain peptidase M2 domain
gptkbp:EC_number 3.4.17.23
gptkbp:encodedBy gptkb:ACE2_gene
gptkbp:Entrez_Gene_ID 59272
gptkbp:expressedIn gptkb:kidney
gptkb:testis
heart
lungs
intestine
gptkbp:foundIn humans
mammals
gptkbp:function catalyzes conversion of angiotensin II to angiotensin 1-7
regulates renin-angiotensin system
gptkbp:glycosylation N-linked
gptkbp:HGNC_ID 13557
https://www.w3.org/2000/01/rdf-schema#label angiotensin I converting enzyme 2
gptkbp:inhibitedBy gptkb:MLN-4760
gptkbp:involvedIn glucose homeostasis
renal function
acute lung injury
amino acid transport
myocardial function
gptkbp:locatedOnChromosome gptkb:X_chromosome
gptkbp:location gptkb:cell_membrane
gptkb:cytoplasm
gptkbp:molecularWeight ~120 kDa
gptkbp:OMIM 300335
gptkbp:orthologIn angiotensin-converting enzyme (ACE)
gptkbp:PDB gptkb:1R42
gptkbp:receptorFor gptkb:COVID-19
gptkb:SARS-CoV
gptkbp:regulates inflammation
blood pressure
fluid balance
gptkbp:relatedTo gptkb:COVID-19
gptkb:cardiovascular_disease
hypertension
gptkbp:structure type I transmembrane glycoprotein
gptkbp:substrate gptkb:angiotensin_II
gptkb:apelin
des-Arg9-bradykinin
gptkbp:UniProtID gptkb:Q9BYF1
gptkbp:bfsParent gptkb:ACE2
gptkbp:bfsLayer 5