|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
PP9284
PRSS10
TTSP2
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:SARS-CoV-2_infection
prostate cancer
|
|
gptkbp:biologicalProcess
|
proteolysis
viral entry into host cell
serine-type endopeptidase activity
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:chromosomeArm
|
21q22.3
|
|
gptkbp:discoveredBy
|
Paoloni-Giacobino et al.
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodes
|
Transmembrane protease, serine 2
|
|
gptkbp:Entrez_Gene_ID
|
7113
ENSG00000184012
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:prostate
gastrointestinal tract
|
|
gptkbp:fullName
|
transmembrane protease, serine 2
|
|
gptkbp:function
|
serine protease activity
cleavage of viral spike proteins
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
11876
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
TMPRSS2
|
|
gptkbp:inhibitors
|
bromhexine
camostat mesylate
nafamostat
|
|
gptkbp:length
|
492 amino acids
|
|
gptkbp:lengthOfGene
|
approximately 44 kb
|
|
gptkbp:locatedOnChromosome
|
chromosome 21
|
|
gptkbp:numberOfExons
|
14
|
|
gptkbp:OMIM
|
602060
|
|
gptkbp:orthologInMouse
|
Tmprss2
|
|
gptkbp:proteinFamily
|
gptkb:LDL_receptor_class_A_domain
transmembrane domain
serine protease domain
scavenger receptor cysteine-rich domain
type II transmembrane serine proteases
|
|
gptkbp:regulates
|
androgen-responsive
|
|
gptkbp:roleInViralEntry
|
activates SARS-CoV-2 spike protein
activates influenza virus hemagglutinin
|
|
gptkbp:significance
|
biomarker for prostate cancer
target for COVID-19 therapeutics
|
|
gptkbp:species
|
gptkb:Homo_sapiens
|
|
gptkbp:symbol
|
gptkb:TMPRSS2
|
|
gptkbp:TMPRSS2-ERG_fusion
|
common in prostate cancer
|
|
gptkbp:UniProtID
|
O15393
|
|
gptkbp:bfsParent
|
gptkb:S-protein
gptkb:ERG
gptkb:human_chromosome_21
gptkb:ACE2_receptor
gptkb:ACE2_gene
|
|
gptkbp:bfsLayer
|
7
|