|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:angiotensin_I_converting_enzyme_2
ACEH
|
|
gptkbp:associatedWith
|
gptkb:COVID-19
gptkb:diabetes_mellitus
heart failure
hypertension
|
|
gptkbp:cleavage
|
gptkb:ADAM17
|
|
gptkbp:cofactor
|
zinc
|
|
gptkbp:discoveredBy
|
Xiao et al.
|
|
gptkbp:discoveredIn
|
2000
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000130234
59272
|
|
gptkbp:enzymeCommissionNumber
|
3.4.17.23
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:kidney
gptkb:testis
heart
endothelial cells
intestine
|
|
gptkbp:fullName
|
gptkb:Angiotensin-converting_enzyme_2
|
|
gptkbp:function
|
regulates blood pressure
regulates cardiovascular and renal function
catalyzes conversion of angiotensin II to angiotensin 1-7
|
|
gptkbp:gene
|
gptkb:ACE2
|
|
gptkbp:glycosylation
|
N-linked
|
|
gptkbp:HGNC_ID
|
HGNC:13557
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ACE2
|
|
gptkbp:inhibitedBy
|
gptkb:MLN-4760
|
|
gptkbp:length
|
805
|
|
gptkbp:locatedOnChromosome
|
X
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:Xp22.2
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
92 kDa
|
|
gptkbp:OMIM
|
300335
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
Ace2
|
|
gptkbp:pathway
|
gptkb:Renin-angiotensin_system
|
|
gptkbp:PDB
|
gptkb:1R42
gptkb:6M17
gptkb:6VW1
|
|
gptkbp:proteinFamily
|
gptkb:peptidase_M2_family
|
|
gptkbp:receptorFor
|
gptkb:COVID-19
gptkb:SARS-CoV
|
|
gptkbp:RefSeq
|
gptkb:NM_021804
|
|
gptkbp:regulates
|
downregulated by SARS-CoV-2 infection
upregulated by interferons
|
|
gptkbp:signalPeptide
|
present
|
|
gptkbp:structureType
|
type I transmembrane glycoprotein
|
|
gptkbp:substrate
|
gptkb:angiotensin_II
gptkb:apelin
|
|
gptkbp:UniProtID
|
gptkb:Q9BYF1
|
|
gptkbp:bfsParent
|
gptkb:COVID-19
|
|
gptkbp:bfsLayer
|
4
|