|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cardiovascular_disease
gptkb:diabetes
gptkb:acute_respiratory_distress_syndrome
hypertension
lung injury
|
|
gptkbp:cleavage
|
gptkb:ADAM17
gptkb:TMPRSS2
|
|
gptkbp:discoveredBy
|
Kuba et al.
|
|
gptkbp:discoveredIn
|
2000
|
|
gptkbp:encodedBy
|
gptkb:ACE2_gene
|
|
gptkbp:expressionHigherIn
|
adults
males
|
|
gptkbp:expressionLowerIn
|
children
|
|
gptkbp:foundIn
|
humans
heart
mammals
lungs
kidneys
intestines
endothelial cells
|
|
gptkbp:fullName
|
gptkb:Angiotensin-converting_enzyme_2
|
|
gptkbp:function
|
vasodilation
anti-inflammatory effects
converts angiotensin II to angiotensin 1-7
regulates renin-angiotensin system
|
|
gptkbp:gene
|
gptkb:ACE2
|
|
gptkbp:glycosylation
|
yes
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ACE2 receptor
|
|
gptkbp:inhibitedBy
|
gptkb:MLN-4760
gptkb:DX600
|
|
gptkbp:interactsWith
|
gptkb:SARS-CoV-2_spike_protein
gptkb:B0AT1_transporter
|
|
gptkbp:involvedIn
|
gptkb:SARS_infection
COVID-19 infection
regulation of blood pressure
amino acid transport
|
|
gptkbp:locatedOnChromosome
|
gptkb:X_chromosome
gptkb:Xp22
|
|
gptkbp:membraneBound
|
yes
|
|
gptkbp:molecularWeight
|
~120 kDa
|
|
gptkbp:orthologIn
|
gptkb:Fox
gptkb:dog
gptkb:meat
gptkb:mouse
gptkb:cat
gptkb:ACE1
bay
right
|
|
gptkbp:PDB
|
gptkb:1R42
|
|
gptkbp:receptorFor
|
gptkb:COVID-19
gptkb:SARS-CoV
gptkb:HCoV-NL63
|
|
gptkbp:regulates
|
interferons
inflammatory cytokines
sex hormones
|
|
gptkbp:solubleForm
|
yes
|
|
gptkbp:structure
|
type I transmembrane protein
contains peptidase domain
|
|
gptkbp:target
|
COVID-19 research
therapeutic drugs
|
|
gptkbp:UniProtID
|
gptkb:Q9BYF1
|
|
gptkbp:bfsParent
|
gptkb:SARS-CoV-2_spike_protein
|
|
gptkbp:bfsLayer
|
6
|