Angiotensin-converting enzyme 2

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:abbreviation	gptkb:ACE2
gptkbp:alternativeSplicing	yes
gptkbp:biologicalProcess	peptidyl-dipeptidase activity
gptkbp:discoveredIn	2000
gptkbp:domain	collectrin domain peptidase M2 domain
gptkbp:EC_number	3.4.17.23
gptkbp:encodedBy	gptkb:ACE2_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000130234 59272
gptkbp:expressedIn	gptkb:kidney gptkb:testis heart lungs liver endothelial cells intestine epithelial cells
gptkbp:foundIn	humans mammals
gptkbp:function	regulates blood pressure catalyzes conversion of angiotensin II to angiotensin 1-7 regulates cardiovascular function regulates renal function
gptkbp:HGNC_ID	13557
gptkbp:inhibitedBy	gptkb:MLN-4760
gptkbp:length	805 amino acids
gptkbp:locatedOnChromosome	gptkb:Xp22.2 gptkb:X_chromosome
gptkbp:location	gptkb:cell_membrane gptkb:plasma_membrane
gptkbp:memberOf	gptkb:renin-angiotensin_system
gptkbp:molecularWeight	80596 Da
gptkbp:OMIM	300335
gptkbp:orthologIn	gptkb:bay gptkb:mouse gptkb:right gptkb:cat
gptkbp:PDB	gptkb:1R42 gptkb:6M17 gptkb:6VW1 6LZG 6M18
gptkbp:receptorFor	gptkb:COVID-19 gptkb:SARS-CoV
gptkbp:RefSeq	gptkb:NM_021804
gptkbp:relatedTo	gptkb:COVID-19 gptkb:cardiovascular_disease gptkb:diabetes_mellitus gptkb:acute_respiratory_distress_syndrome hypertension
gptkbp:UniProtID	gptkb:Q9BYF1
gptkbp:bfsParent	gptkb:ACE2
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	Angiotensin-converting enzyme 2