Angiotensin-converting enzyme 2

URI: https://gptkb.org/entity/Angiotensin-converting_enzyme_2
GPTKB entity
Statements (56)
Predicate Object
gptkbp:instanceOf gptkb:enzyme
gptkbp:abbreviation gptkb:ACE2
gptkbp:alternativeSplicing yes
gptkbp:biologicalProcess peptidyl-dipeptidase activity
gptkbp:discoveredIn 2000
gptkbp:domain collectrin domain
peptidase M2 domain
gptkbp:EC_number 3.4.17.23
gptkbp:encodedBy gptkb:ACE2_gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000130234
59272
gptkbp:expressedIn gptkb:kidney
gptkb:testis
heart
lungs
liver
endothelial cells
intestine
epithelial cells
gptkbp:foundIn humans
mammals
gptkbp:function regulates blood pressure
catalyzes conversion of angiotensin II to angiotensin 1-7
regulates cardiovascular function
regulates renal function
gptkbp:HGNC_ID 13557
https://www.w3.org/2000/01/rdf-schema#label Angiotensin-converting enzyme 2
gptkbp:inhibitedBy gptkb:MLN-4760
gptkbp:length 805 amino acids
gptkbp:locatedOnChromosome gptkb:Xp22.2
gptkb:X_chromosome
gptkbp:location gptkb:cell_membrane
gptkb:plasma_membrane
gptkbp:memberOf gptkb:renin-angiotensin_system
gptkbp:molecularWeight 80596 Da
gptkbp:OMIM 300335
gptkbp:orthologIn gptkb:mouse
gptkb:cat
bay
right
gptkbp:PDB gptkb:1R42
gptkb:6M17
gptkb:6VW1
6LZG
6M18
gptkbp:receptorFor gptkb:COVID-19
gptkb:SARS-CoV
gptkbp:RefSeq gptkb:NM_021804
gptkbp:relatedTo gptkb:COVID-19
gptkb:cardiovascular_disease
gptkb:diabetes_mellitus
gptkb:acute_respiratory_distress_syndrome
hypertension
gptkbp:UniProtID gptkb:Q9BYF1
gptkbp:bfsParent gptkb:ACE2
gptkbp:bfsLayer 5