hypoxia-inducible factor 1-alpha

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:activatesTranscriptionOf	gptkb:LDHA gptkb:EPO gptkb:GLUT1 gptkb:VEGF
gptkbp:degradedBy	gptkb:proteasome oxygen levels
gptkbp:discoveredBy	gptkb:Gregg_L._Semenza
gptkbp:encodedBy	gptkb:HIF1A_gene
gptkbp:Entrez_Gene_ID	3091
gptkbp:formsComplexWith	gptkb:HIF-1β
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	transcription factor
https://www.w3.org/2000/01/rdf-schema#label	hypoxia-inducible factor 1-alpha
gptkbp:involvedIn	angiogenesis erythropoiesis metabolic adaptation tumor progression cellular response to low oxygen
gptkbp:locale	gptkb:nucleus
gptkbp:locatedOnChromosome	14q23.2
gptkbp:NobelPrizeYear	gptkb:2019_Nobel_Prize_in_Physiology_or_Medicine
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Rattus_norvegicus
gptkbp:postTranslationalModification	ubiquitination hydroxylation
gptkbp:regulates	response to hypoxia
gptkbp:structure	PAS domain basic helix-loop-helix domain
gptkbp:UniProtID	Q16665
gptkbp:bfsParent	gptkb:von_Hippel-Lindau_protein gptkb:Aryl_hydrocarbon_receptor_nuclear_translocator_2 gptkb:Aryl_hydrocarbon_receptor_nuclear_translocator_2_protein gptkb:HIF1A_gene
gptkbp:bfsLayer	8