tumor necrosis factor beta

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:cytokine gptkb:protein
gptkbp:alsoKnownAs	gptkb:lymphotoxin_alpha
gptkbp:cellularComponent	gptkb:plasma_membrane extracellular space
gptkbp:discoveredBy	D. W. D. Barnes Nancy H. Ruddle
gptkbp:discoveredIn	1968
gptkbp:encodedBy	gptkb:LTA_gene
gptkbp:Entrez_Gene_ID	4049
gptkbp:expressedIn	gptkb:natural_killer_cells gptkb:B_cells gptkb:T_cells
gptkbp:foundIn	humans mammals
gptkbp:function	inflammation regulation of immune response induction of cell death
gptkbp:gene	gptkb:LTA
gptkbp:GO_term	gptkb:GO:0005125
gptkbp:homologInRat	Lta
gptkbp:involvedIn	gptkb:NF-kappaB_signaling_pathway immune system process cytokine-mediated signaling pathway
gptkbp:locatedOnChromosome	chromosome 6p21.3
gptkbp:memberOf	gptkb:tumor_necrosis_factor_superfamily
gptkbp:molecularWeight	25 kDa
gptkbp:OMIM	153440
gptkbp:orthologInMouse	Lta
gptkbp:PDB	gptkb:1TNR
gptkbp:producedBy	activated lymphocytes
gptkbp:recipient	TNF receptor 1 TNF receptor 2
gptkbp:regulates	apoptosis cell proliferation differentiation lymphoid organ development upregulated by antigens upregulated by mitogens
gptkbp:relatedTo	gptkb:tumor_necrosis_factor_alpha
gptkbp:role	gptkb:cancer autoimmune diseases inflammatory diseases
gptkbp:sequence	polypeptide
gptkbp:structure	homotrimer
gptkbp:UniProtID	P01374
gptkbp:bfsParent	gptkb:tumor_necrosis_factor_superfamily gptkb:Etanercept gptkb:etanercept
gptkbp:bfsLayer	8
https://www.w3.org/2000/01/rdf-schema#label	tumor necrosis factor beta