tumor necrosis factor beta

URI: https://gptkb.org/entity/tumor_necrosis_factor_beta
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
cytokine
gptkbp:alsoKnownAs gptkb:lymphotoxin_alpha
gptkbp:cellularComponent gptkb:plasma_membrane
extracellular space
gptkbp:discoveredBy D. W. D. Barnes
Nancy H. Ruddle
gptkbp:discoveredIn 1968
gptkbp:encodedBy gptkb:LTA_gene
gptkbp:Entrez_Gene_ID 4049
gptkbp:expressedIn gptkb:natural_killer_cells
gptkb:B_cells
gptkb:T_cells
gptkbp:foundIn humans
mammals
gptkbp:function inflammation
regulation of immune response
induction of cell death
gptkbp:gene gptkb:LTA
gptkbp:GO_term gptkb:GO:0005125
gptkbp:homologInRat Lta
https://www.w3.org/2000/01/rdf-schema#label tumor necrosis factor beta
gptkbp:involvedIn gptkb:NF-kappaB_signaling_pathway
immune system process
cytokine-mediated signaling pathway
gptkbp:locatedOnChromosome chromosome 6p21.3
gptkbp:memberOf gptkb:tumor_necrosis_factor_superfamily
gptkbp:molecularWeight 25 kDa
gptkbp:OMIM 153440
gptkbp:orthologInMouse Lta
gptkbp:PDB gptkb:1TNR
gptkbp:producedBy activated lymphocytes
gptkbp:recipient TNF receptor 1
TNF receptor 2
gptkbp:regulates apoptosis
cell proliferation
differentiation
lymphoid organ development
upregulated by antigens
upregulated by mitogens
gptkbp:relatedTo gptkb:tumor_necrosis_factor_alpha
gptkbp:role gptkb:cancer
autoimmune diseases
inflammatory diseases
gptkbp:sequence polypeptide
gptkbp:structure homotrimer
gptkbp:UniProtID P01374
gptkbp:bfsParent gptkb:tumor_necrosis_factor_superfamily
gptkb:etanercept
gptkbp:bfsLayer 7