|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:alsoKnownAs
|
TACE
tumor necrosis factor-alpha converting enzyme
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
inflammatory diseases
rheumatoid arthritis
|
|
gptkbp:biologicalProcess
|
development
cell signaling
immune response
proteolysis
|
|
gptkbp:discoveredBy
|
1997
|
|
gptkbp:encodedBy
|
ADAM17 gene
|
|
gptkbp:Entrez_Gene_ID
|
6868
ENSG00000151694
|
|
gptkbp:enzymeClassification
|
EC 3.4.24.86
|
|
gptkbp:expressedIn
|
many tissues
immune cells
epithelial cells
|
|
gptkbp:fullName
|
A Disintegrin and Metalloproteinase domain-containing protein 17
|
|
gptkbp:function
|
cleaves membrane proteins
releases TNF-alpha
shedding of cell surface proteins
|
|
gptkbp:gene
|
gptkb:ADAM17
|
|
gptkbp:HGNC_ID
|
HGNC:195
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ADAM17
|
|
gptkbp:inhibitedBy
|
GW280264X
TAPI-1
|
|
gptkbp:locatedOnChromosome
|
chromosome 2p25
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:Golgi_apparatus
|
|
gptkbp:molecularWeight
|
~100 kDa
|
|
gptkbp:OMIM
|
603639
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse
gptkb:zebrafish
right
|
|
gptkbp:PDB
|
3E8R
|
|
gptkbp:RefSeq
|
NM_003183
|
|
gptkbp:regulates
|
phosphorylation
protein-protein interactions
|
|
gptkbp:structure
|
cytoplasmic tail
disintegrin domain
metalloprotease domain
|
|
gptkbp:substrate
|
gptkb:Notch_receptor
L-selectin
EGFR ligands
TNF-alpha precursor
|
|
gptkbp:UniProtID
|
P78536
|
|
gptkbp:bfsParent
|
gptkb:ACE2
|
|
gptkbp:bfsLayer
|
5
|