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gptkbp:instanceOf
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gptkb:enzyme
|
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gptkbp:alternativeName
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gptkb:Type_II_topoisomerase
DNA topoisomerase II
topo II
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gptkbp:biologicalProcess
|
DNA repair
DNA replication
chromosome segregation
ATP-dependent DNA topoisomerase activity
|
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gptkbp:cellularComponent
|
gptkb:nucleus
|
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gptkbp:cofactor
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gptkb:ATP
|
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gptkbp:discoveredBy
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gptkb:James_C._Wang
|
|
gptkbp:discoveredIn
|
1971
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gptkbp:enzymeCommissionNumber
|
EC 5.99.1.3
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gptkbp:foundIn
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gptkb:Bacteria
eukaryotes
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|
gptkbp:function
|
removes DNA supercoils
alters the topologic states of DNA
introduces transient double-strand breaks in DNA
untangles DNA during replication and transcription
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gptkbp:gene
|
TOP2A
TOP2B
|
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gptkbp:hasIsoform
|
gptkb:topoisomerase_II_alpha
topoisomerase II beta
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
topoisomerase II
|
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gptkbp:inhibitedBy
|
ICRF-193
merbarone
|
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gptkbp:locatedOnChromosome
|
human chromosome 17q21-22 (TOP2A)
human chromosome 3p24 (TOP2B)
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gptkbp:molecularWeight
|
~170 kDa (human TOP2A)
|
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gptkbp:mutationAssociatedWith
|
drug resistance
genomic instability
|
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gptkbp:presentIn
|
gptkb:Mus_musculus
gptkb:Saccharomyces_cerevisiae
gptkb:Homo_sapiens
gptkb:Bacteria
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gptkbp:relatedTo
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gptkb:DNA_gyrase
gptkb:topoisomerase_I
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gptkbp:requires
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cell division
meiosis
mitosis
|
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gptkbp:structure
|
homodimer
|
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gptkbp:subclassOf
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gptkb:enzyme
gptkb:isomerase
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gptkbp:target
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gptkb:doxorubicin
anticancer drugs
antineoplastic agent
teniposide
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gptkbp:bfsParent
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gptkb:enzyme
|
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gptkbp:bfsLayer
|
5
|