Statements (33)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:enzyme |
| gptkbp:catalyzes |
ATP-dependent breakage and reunion of double-stranded DNA
|
| gptkbp:compatibleWith |
archaea
eukaryotes |
| gptkbp:discoveredBy |
gptkb:James_C._Wang
|
| gptkbp:discoveredIn |
1976
|
| gptkbp:EC_number |
5.6.2.2
|
| gptkbp:foundIn |
gptkb:Bacteria
|
| gptkbp:function |
introduces negative supercoils into DNA
relieves torsional strain during DNA replication |
| gptkbp:gene |
gptkb:gyrA
gptkb:gyrB |
| https://www.w3.org/2000/01/rdf-schema#label |
DNA gyrase
|
| gptkbp:inhibitedBy |
gptkb:nalidixic_acid
gptkb:novobiocin gptkb:oxolinic_acid ciprofloxacin |
| gptkbp:memberOf |
type II topoisomerases
|
| gptkbp:presentIn |
gptkb:Mycobacterium_tuberculosis
gptkb:Bacteria |
| gptkbp:requires |
gptkb:ATP
bacterial DNA replication |
| gptkbp:role |
transcription regulation
chromosome segregation plasmid maintenance |
| gptkbp:structure |
heterotetramer (A2B2)
|
| gptkbp:subunit |
gptkb:GyrA
gptkb:GyrB |
| gptkbp:target |
gptkb:novobiocin
quinolone antibiotics |
| gptkbp:bfsParent |
gptkb:enzyme
|
| gptkbp:bfsLayer |
5
|