Statements (23)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:alternativeName |
gptkb:Type_I_topoisomerase
DNA topoisomerase I |
| gptkbp:cofactor |
none required
|
| gptkbp:discoveredBy |
gptkb:James_C._Wang
|
| gptkbp:discoveredIn |
1971
|
| gptkbp:EC_number |
5.99.1.2
|
| gptkbp:foundIn |
prokaryotes
eukaryotes |
| gptkbp:function |
relaxes supercoiled DNA
|
| gptkbp:gene |
TOP1
|
| https://www.w3.org/2000/01/rdf-schema#label |
topoisomerase I
|
| gptkbp:inhibitedBy |
gptkb:camptothecin
|
| gptkbp:mechanismOfAction |
creates transient single-strand breaks in DNA
|
| gptkbp:mutationAssociatedWith |
genomic instability
|
| gptkbp:role_in_cell |
DNA repair
DNA replication DNA transcription |
| gptkbp:significance |
target for anticancer drugs
|
| gptkbp:structure |
monomeric protein
|
| gptkbp:substrate |
gptkb:gene
|
| gptkbp:bfsParent |
gptkb:enzyme
|
| gptkbp:bfsLayer |
5
|