|
gptkbp:instanceOf
|
gptkb:serine_protease
gptkb:enzyme
|
|
gptkbp:activatedBy
|
prothrombinase complex
|
|
gptkbp:activeSiteResidue
|
Asp102
His57
Ser195
|
|
gptkbp:alternativeName
|
gptkb:coagulation_factor_IIa
gptkb:serine_protease_1
factor IIa
|
|
gptkbp:associatedWith
|
hemophilia
thrombosis
disseminated intravascular coagulation
|
|
gptkbp:CASNumber
|
9002-04-4
|
|
gptkbp:cleavage
|
gptkb:fibrinogen
gptkb:factor_XI
gptkb:protease-activated_receptor_1_(PAR1)
factor V
factor VIII
factor XIII
|
|
gptkbp:cofactor
|
phospholipids
calcium ions
|
|
gptkbp:discoveredBy
|
gptkb:Alexander_Schmidt
|
|
gptkbp:discoveredIn
|
1872
|
|
gptkbp:EC_number
|
3.4.21.5
|
|
gptkbp:encodedBy
|
F2 gene
|
|
gptkbp:function
|
converts fibrinogen to fibrin
activates coagulation factors V, VIII, XI, XIII
activates platelets
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
thrombin (F2)
|
|
gptkbp:inhibitedBy
|
gptkb:antithrombin
gptkb:heparin
gptkb:dabigatran
hirudin
|
|
gptkbp:locatedIn
|
blood plasma
|
|
gptkbp:locatedOnChromosome
|
chromosome 11p11-q12 (human)
|
|
gptkbp:medicalUse
|
topical hemostatic agent
|
|
gptkbp:molecularWeight
|
~36 kDa
|
|
gptkbp:OMIM
|
176930
|
|
gptkbp:pathway
|
coagulation cascade
|
|
gptkbp:PDB
|
1PPB
|
|
gptkbp:predecessor
|
prothrombin
|
|
gptkbp:role
|
wound healing
inflammation
blood coagulation
|
|
gptkbp:species
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:structure
|
two polypeptide chains (A and B) linked by disulfide bonds
|
|
gptkbp:substrate
|
gptkb:fibrinogen
protease-activated receptors (PARs)
|
|
gptkbp:UniProtID
|
P00734
|
|
gptkbp:bfsParent
|
gptkb:DB09054
gptkb:DB12023
|
|
gptkbp:bfsLayer
|
6
|