Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activatedBy |
factor V
factor VIII factor XIII protein C |
| gptkbp:alsoKnownAs |
gptkb:thrombin
|
| gptkbp:cleavage |
gptkb:fibrinogen
protease-activated receptors |
| gptkbp:discoveredBy |
Charles H. Best (prothrombin)
|
| gptkbp:EC_number |
3.4.21.5
|
| gptkbp:encodedBy |
F2 gene
|
| gptkbp:foundIn |
gptkb:plasma
|
| gptkbp:function |
converts fibrinogen to fibrin
|
| https://www.w3.org/2000/01/rdf-schema#label |
coagulation factor IIa
|
| gptkbp:inhibitedBy |
gptkb:antithrombin
gptkb:heparin hirudin |
| gptkbp:involvedIn |
blood coagulation
|
| gptkbp:locatedOnChromosome |
11p11-q12 (F2 gene)
|
| gptkbp:medicalUse |
target for anticoagulant drugs
|
| gptkbp:molecularWeight |
approximately 37 kDa
|
| gptkbp:producedBy |
prothrombin
|
| gptkbp:role |
hemostasis
|
| gptkbp:significance |
deficiency leads to bleeding disorders
excess leads to thrombosis |
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:structure |
gptkb:serine_protease
|
| gptkbp:UniProtID |
P00734
|
| gptkbp:bfsParent |
gptkb:Thrombin
gptkb:thrombin |
| gptkbp:bfsLayer |
6
|