DB01586

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:antidote gptkb:idarucizumab
gptkbp:approvalYear 2010
gptkbp:ATCCode B01AE07
gptkbp:bioavailability 6.5%
gptkbp:brand gptkb:Pradaxa
gptkbp:CASNumber 211914-51-1
gptkbp:contraindication patients with active pathological bleeding
patients with mechanical prosthetic heart valves
gptkbp:drugInteraction gptkb:NSAIDs
anticoagulants
antiplatelet agents
P-glycoprotein inhibitors
gptkbp:eliminatedIn urine
gptkbp:eliminationHalfLife 12-17 hours
gptkbp:excretion renal
gptkbp:hasDrugBankCategory gptkb:anticoagulant
gptkbp:hasInChIKey PTZSUBHDPIDFOT-UHFFFAOYSA-N
gptkbp:hasMolecularFormula C34H41N7O5
gptkbp:hasReversalAgent gptkb:idarucizumab
gptkbp:hasSMILES CC(C)N1C(=O)NC(C(=O)N(C2CC2)C(=O)N(C)C3=CC=CC=C3)C1=O
gptkbp:hasUNII 2ZC53Y6Z98
https://www.w3.org/2000/01/rdf-schema#label DB01586
gptkbp:indication treatment and prevention of deep vein thrombosis
treatment and prevention of pulmonary embolism
prevention of stroke and systemic embolism in patients with non-valvular atrial fibrillation
gptkbp:legalStatus prescription only
patented
gptkbp:manufacturer gptkb:Boehringer_Ingelheim
gptkbp:marketedIn gptkb:Australia
gptkb:Canada
gptkb:European_Union
gptkb:United_States
gptkbp:mechanismOfAction direct thrombin inhibitor
gptkbp:metabolism hepatic
gptkbp:molecularWeight 627.74
gptkbp:name gptkb:Dabigatran
gptkbp:pregnancyCategory C (US)
gptkbp:proteinBinding 35%
gptkbp:PubChem_CID gptkb:CHEMBL1201197
148124
D08167
gptkbp:routeOfAdministration oral
gptkbp:sideEffect bleeding
dyspepsia
gastrointestinal upset
gptkbp:status true
gptkbp:target gptkb:thrombin_(F2)
gptkbp:toxicity overdose may cause severe bleeding
gptkbp:bfsParent gptkb:ursodeoxycholic_acid
gptkbp:bfsLayer 6