protease-activated receptor 1 (PAR1)
GPTKB entity
Statements (48)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
gptkb:G_protein-coupled_receptor |
| gptkbp:activatedBy |
gptkb:thrombin
gptkb:trypsin |
| gptkbp:cleavage |
serine proteases
|
| gptkbp:discoveredIn |
1991
|
| gptkbp:encodedBy |
F2R gene
|
| gptkbp:enemyOf |
atopaxar
vorapaxar |
| gptkbp:Entrez_Gene_ID |
2149
|
| gptkbp:expressedIn |
gptkb:neurons
platelets endothelial cells smooth muscle cells |
| gptkbp:foundIn |
gptkb:Homo_sapiens
|
| gptkbp:function |
mediates cellular responses to proteases
|
| gptkbp:HGNC_ID |
3537
|
| gptkbp:involvedIn |
inflammation
hemostasis platelet activation |
| gptkbp:locatedOnChromosome |
5q13
|
| gptkbp:location |
gptkb:cell_membrane
|
| gptkbp:modulatedBy |
apoptosis
cell proliferation gene expression inflammatory response smooth muscle contraction neuronal signaling endothelial barrier function platelet aggregation cytoskeletal rearrangement vascular permeability |
| gptkbp:OMIM |
601425
|
| gptkbp:otherName |
F2R
coagulation factor II receptor |
| gptkbp:PDB |
3VW7
|
| gptkbp:relatedTo |
gptkb:protease-activated_receptor_4_(PAR4)
protease-activated receptor 2 (PAR2) protease-activated receptor 3 (PAR3) |
| gptkbp:structure |
seven transmembrane domains
|
| gptkbp:targetOfDrug |
antithrombotic therapy
|
| gptkbp:type |
G12/13 pathway
Gi pathway Gq/11 pathway |
| gptkbp:UniProtID |
P25116
|
| gptkbp:bfsParent |
gptkb:thrombin
|
| gptkbp:bfsLayer |
7
|
| https://www.w3.org/2000/01/rdf-schema#label |
protease-activated receptor 1 (PAR1)
|