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gptkbp:instanceOf
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gptkb:enzyme
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|
gptkbp:catalyzes
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hydrolysis of peptide bonds
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gptkbp:contains
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serine residue at active site
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gptkbp:discoveredBy
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gptkb:John_H._Northrop
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gptkbp:EC_number
|
EC 3.4.21.-
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gptkbp:example
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gptkb:elastase
gptkb:thrombin
gptkb:trypsin
subtilisin
chymotrypsin
plasmin
proteinase K
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gptkbp:family
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S1 family
S28 family
S33 family
S8 family
S9 family
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gptkbp:firstDescribed
|
1930s
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gptkbp:foundIn
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gptkb:Bacteria
animals
plants
viruses
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gptkbp:GO_term
|
GO:0004252
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|
https://www.w3.org/2000/01/rdf-schema#label
|
Serine protease
|
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gptkbp:inhibitedBy
|
gptkb:DFP
gptkb:aprotinin
gptkb:serpins
PMSF
|
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gptkbp:mechanismOfAction
|
catalytic triad
nucleophilic attack by serine
|
|
gptkbp:mutationAssociatedWith
|
can cause disease
|
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gptkbp:relatedTo
|
gptkb:aspartic_protease
gptkb:cysteine_protease
metalloprotease
|
|
gptkbp:role
|
apoptosis
development
cell signaling
immune response
digestion
blood coagulation
fibrinolysis
|
|
gptkbp:structure
|
alpha/beta fold
beta-barrel
|
|
gptkbp:usedIn
|
gptkb:biotechnology
research
therapeutics
detergents
protein digestion assays
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gptkbp:bfsParent
|
gptkb:Peptidase
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gptkbp:bfsLayer
|
7
|