serotonin transporter (SERT)

URI: https://gptkb.org/entity/serotonin_transporter_(SERT)

GPTKB entity

Statements (51)

Predicate	Object
gptkbp:instanceOf	gptkb:cell_membrane gptkb:solute_carrier_family
gptkbp:alternativeName	gptkb:SLC6A4_protein 5-HT transporter
gptkbp:associatedWith	gptkb:autism_spectrum_disorder irritable bowel syndrome pulmonary arterial hypertension
gptkbp:discoveredBy	1990s
gptkbp:encodedBy	gptkb:SLC6A4_gene
gptkbp:expressedIn	gptkb:placenta platelets intestinal mucosa
gptkbp:function	reuptake of serotonin from synaptic cleft
gptkbp:hasPolymorphism	gptkb:5-HTTLPR
https://www.w3.org/2000/01/rdf-schema#label	serotonin transporter (SERT)
gptkbp:inhibitedBy	gptkb:citalopram gptkb:escitalopram gptkb:paroxetine gptkb:sertraline gptkb:venlafaxine gptkb:amitriptyline gptkb:imipramine gptkb:duloxetine gptkb:fluoxetine gptkb:clomipramine increases synaptic serotonin
gptkbp:locatedOnChromosome	gptkb:chromosome_17q11.2
gptkbp:location	central nervous system peripheral nervous system presynaptic neuron membrane
gptkbp:molecularWeight	~70 kDa
gptkbp:OMIM	182138
gptkbp:orthologIn	gptkb:dopamine_transporter_(DAT) norepinephrine transporter (NET)
gptkbp:regulates	phosphorylation protein-protein interactions membrane trafficking
gptkbp:significance	implicated in depression implicated in anxiety disorders implicated in obsessive-compulsive disorder
gptkbp:species	gptkb:Mus_musculus gptkb:Homo_sapiens
gptkbp:structure	12 transmembrane domains
gptkbp:target	gptkb:tricyclic_antidepressants gptkb:MDMA cocaine selective serotonin reuptake inhibitors (SSRIs)
gptkbp:transportation	gptkb:serotonin_(5-HT)
gptkbp:UniProtID	gptkb:P31645
gptkbp:bfsParent	gptkb:Serotonin
gptkbp:bfsLayer	6