Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
neurotransmitter
|
| gptkbp:actsOn |
gptkb:ligand-gated_ion_channels
gptkb:G_protein-coupled_receptors |
| gptkbp:associated_disorder |
gptkb:depression
anxiety migraine irritable bowel syndrome |
| gptkbp:biosynthesized_from |
tryptophan
|
| gptkbp:chemicalFormula |
C10H12N2O
|
| gptkbp:color |
white to off-white (as solid)
|
| gptkbp:degradedBy |
gptkb:monoamine_oxidase
|
| gptkbp:discoveredBy |
gptkb:Maurice_M._Rapport
|
| gptkbp:discoveredIn |
1948
|
| gptkbp:foundIn |
gastrointestinal tract
central nervous system blood platelets |
| gptkbp:function |
regulation of mood
regulation of digestion regulation of appetite regulation of memory regulation of learning regulation of sleep regulation of sexual desire regulation of social behavior |
| https://www.w3.org/2000/01/rdf-schema#label |
serotonin (5-HT)
|
| gptkbp:IUPACName |
5-hydroxytryptamine
|
| gptkbp:meltingPoint |
167°C
|
| gptkbp:metabolism |
5-hydroxyindoleacetic acid (5-HIAA)
|
| gptkbp:molecularWeight |
176.215 g/mol
|
| gptkbp:predecessor |
tryptophan
|
| gptkbp:receptor_type |
5-HT1
5-HT2 5-HT3 5-HT4 5-HT5 5-HT6 5-HT7 |
| gptkbp:releaseDate |
presynaptic neurons
|
| gptkbp:reuptake_by |
gptkb:serotonin_transporter_(SERT)
|
| gptkbp:solubility |
water soluble
|
| gptkbp:storage_location |
synaptic vesicles
|
| gptkbp:systematicName |
3-(2-aminoethyl)-1H-indol-5-ol
|
| gptkbp:target |
gptkb:tricyclic_antidepressants
antipsychotic drugs psychedelic drugs antiemetic drugs monoamine oxidase inhibitors (MAOIs) selective serotonin reuptake inhibitors (SSRIs) serotonin-norepinephrine reuptake inhibitors (SNRIs) |
| gptkbp:bfsParent |
gptkb:serotonin_transporter_pathway
gptkb:serotonin_transporter_(SERT) |
| gptkbp:bfsLayer |
7
|