|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alsoKnownAs
|
gptkb:5-HTT
gptkb:SERT
gptkb:solute_carrier_family_6_member_4
|
|
gptkbp:associatedWith
|
gptkb:depression
gptkb:autism_spectrum_disorder
gptkb:obsessive-compulsive_disorder
anxiety
|
|
gptkbp:discoveredIn
|
1990s
|
|
gptkbp:encodes
|
gptkb:serotonin_transporter
|
|
gptkbp:Entrez_Gene_ID
|
6532
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:placenta
brain
|
|
gptkbp:hasClinicalTest
|
pharmacogenetic testing
|
|
gptkbp:hasIntronPolymorphism
|
gptkb:STin2_VNTR
|
|
gptkbp:hasPolymorphism
|
gptkb:5-HTTLPR
|
|
gptkbp:hasPromoterPolymorphism
|
gptkb:5-HTTLPR
|
|
gptkbp:HGNC_ID
|
11050
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
SLC6A4 gene
|
|
gptkbp:involvedIn
|
neurodevelopment
stress response
antidepressant response
serotonergic synaptic transmission
|
|
gptkbp:length
|
630 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q11.2
|
|
gptkbp:mutationAssociatedWith
|
gptkb:panic_disorder
irritable bowel syndrome
alcohol dependence
|
|
gptkbp:OMIM
|
182138
|
|
gptkbp:orthologInMouse
|
gptkb:Slc6a4
|
|
gptkbp:product
|
gptkb:cell_membrane
integral membrane protein
neurotransmitter transporter
|
|
gptkbp:proteinFamily
|
gptkb:solute_carrier_family_6
|
|
gptkbp:regulates
|
cognition
emotion
memory
learning
sleep
appetite
mood
serotonin reuptake
|
|
gptkbp:target
|
gptkb:selective_serotonin_reuptake_inhibitors
|
|
gptkbp:transmembraneDomains
|
12
|
|
gptkbp:UniProtID
|
gptkb:P31645
|
|
gptkbp:bfsParent
|
gptkb:5-HTTLPR
gptkb:SLC6A4_protein
gptkb:serotonin_transporter_pathway
gptkb:solute_carrier_family_6_member_4
gptkb:serotonin_transporter
gptkb:serotonin_transporter_(SERT)
|
|
gptkbp:bfsLayer
|
7
|