dopamine transporter (DAT)

URI: https://gptkb.org/entity/dopamine_transporter_(DAT)
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
amino acid transporter
gptkbp:alternativeName gptkb:DAT1
gptkb:SLC6A3
dopamine active transporter
gptkbp:associatedWith gptkb:Parkinson's_disease
bipolar disorder
ADHD
substance abuse
gptkbp:discoveredBy gptkb:Susan_Amara
gptkbp:discoveredIn 1991
gptkbp:encodedBy gptkb:SLC6A3_gene
gptkbp:Entrez_Gene_ID 6531
gptkbp:expressedIn gptkb:striatum
gptkb:ventral_tegmental_area
substantia nigra
gptkbp:foundIn presynaptic neuron
gptkbp:function reuptake of dopamine from synaptic cleft
https://www.w3.org/2000/01/rdf-schema#label dopamine transporter (DAT)
gptkbp:inhibitedBy gptkb:bupropion
gptkb:methylphenidate
cocaine
amphetamines
gptkbp:locatedOnChromosome gptkb:5p15.3
gptkbp:location gptkb:plasma_membrane
gptkbp:mechanismOfAction chloride-dependent dopamine reuptake
sodium-dependent dopamine reuptake
gptkbp:medicalUse target for psychostimulant drugs
gptkbp:memberOf gptkb:solute_carrier_family
gptkbp:molecularWeight approximately 70 kDa
gptkbp:mutationAssociatedWith gptkb:dopamine_transporter_deficiency_syndrome
infantile parkinsonism-dystonia
gptkbp:OMIM 126455
gptkbp:regulates phosphorylation
protein-protein interactions
dopaminergic neurotransmission
trafficking to and from plasma membrane
gptkbp:species gptkb:human
gptkb:mouse
right
gptkbp:structure 12 transmembrane domains
gptkbp:target gptkb:bupropion
gptkb:modafinil
gptkb:methylphenidate
cocaine
amphetamine
gptkbp:UniProtID gptkb:Q01959
gptkbp:bfsParent gptkb:serotonin_transporter_(SERT)
gptkbp:bfsLayer 7