|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
serine
|
|
gptkbp:catalyzes
|
hydrolysis of peptide bonds
|
|
gptkbp:cofactor
|
none required
|
|
gptkbp:contains
|
serine residue at active site
|
|
gptkbp:discoveredBy
|
gptkb:John_H._Northrop
|
|
gptkbp:EC_number
|
3.4.21.-
|
|
gptkbp:example
|
gptkb:elastase
gptkb:factor_Xa
gptkb:thrombin
gptkb:trypsin
subtilisin
chymotrypsin
plasmin
|
|
gptkbp:family
|
gptkb:peptidase_S1_family
peptidase S8 family
peptidase S9 family
|
|
gptkbp:firstDescribed
|
1930s
|
|
gptkbp:foundIn
|
gptkb:Bacteria
animals
plants
|
|
gptkbp:function
|
cell signaling
immune response
blood coagulation
protein digestion
|
|
gptkbp:GO_term
|
GO:0004252
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
serine endopeptidase
|
|
gptkbp:inhibitedBy
|
gptkb:serpins
diisopropyl fluorophosphate
phenylmethylsulfonyl fluoride
|
|
gptkbp:mechanismOfAction
|
catalytic triad
|
|
gptkbp:structure
|
gptkb:alpha/beta_hydrolase_fold
trypsin-like fold
|
|
gptkbp:substrate
|
proteins
peptides
|
|
gptkbp:bfsParent
|
gptkb:EC_3.4.21.26
gptkb:enteropeptidase
|
|
gptkbp:bfsLayer
|
7
|