|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
gptkb:aspartate
serine
histidine
|
|
gptkbp:alternativeName
|
gptkb:post-proline_cleaving_enzyme
gptkb:prolyl_oligopeptidase
gptkb:prolyl_serine_peptidase
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:depression
schizophrenia
|
|
gptkbp:biologicalProcess
|
peptidase activity
|
|
gptkbp:CASNumber
|
gptkb:9075-44-1
|
|
gptkbp:catalyzes
|
hydrolysis of peptide bonds at the carboxyl side of proline residues
|
|
gptkbp:cofactor
|
none
|
|
gptkbp:discoveredBy
|
gptkb:Walter_E._Brocklehurst
|
|
gptkbp:discoveredIn
|
1978
|
|
gptkbp:EC_number
|
3.4.21.106
|
|
gptkbp:enzymeClassification
|
gptkb:serine_endopeptidase
|
|
gptkbp:foundIn
|
gptkb:Bacteria
mammals
plants
|
|
gptkbp:function
|
peptide hormone processing
regulation of neuropeptide activity
|
|
gptkbp:gene
|
gptkb:PREP
|
|
gptkbp:GO_term
|
GO:0008236
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EC 3.4.21.106
|
|
gptkbp:inhibitedBy
|
gptkb:JTP-4819
gptkb:Z-Pro-prolinal
S-17092
|
|
gptkbp:locatedOnChromosome
|
gptkb:16p13.3_(human)
|
|
gptkbp:location
|
gptkb:cytoplasm
|
|
gptkbp:notSubstrate
|
large proteins
|
|
gptkbp:optimum_pH
|
7.5
|
|
gptkbp:optimumTemperature
|
37°C
|
|
gptkbp:PDB
|
gptkb:1E5T
gptkb:1QFS
gptkb:3DDU
|
|
gptkbp:structure
|
gptkb:alpha/beta_hydrolase_fold
|
|
gptkbp:substrate
|
short proline-containing peptides
|
|
gptkbp:systematicName
|
gptkb:prolyl_endopeptidase
|
|
gptkbp:taxonomicDistribution
|
gptkb:Eukaryota
gptkb:Bacteria
|
|
gptkbp:UniProtID
|
P48147
|
|
gptkbp:bfsParent
|
gptkb:HPN
|
|
gptkbp:bfsLayer
|
7
|