|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
gptkb:aspartate
serine
histidine
|
|
gptkbp:alternativeName
|
gptkb:uPA
gptkb:urokinase-type_plasminogen_activator
|
|
gptkbp:associatedWith
|
stroke
thrombosis
cancer metastasis
|
|
gptkbp:CASNumber
|
9039-53-6
|
|
gptkbp:catalyzes
|
conversion of plasminogen to plasmin
|
|
gptkbp:cofactor
|
none required
|
|
gptkbp:discoveredBy
|
Morten P. Schousboe (purification, 1947)
|
|
gptkbp:EC_number
|
3.4.21.26
|
|
gptkbp:Enzyme_Commission
|
gptkb:International_Union_of_Biochemistry_and_Molecular_Biology
|
|
gptkbp:enzymeClassification
|
gptkb:peptidase_S1_family
gptkb:serine_endopeptidase
|
|
gptkbp:expressedIn
|
macrophages
endothelial cells
kidney cells
|
|
gptkbp:foundIn
|
humans
other mammals
|
|
gptkbp:function
|
fibrinolysis
extracellular matrix degradation
|
|
gptkbp:gene
|
gptkb:PLAU
|
|
gptkbp:GO_term
|
GO:0004252
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
EC 3.4.21.26
|
|
gptkbp:inhibitedBy
|
gptkb:plasminogen_activator_inhibitor-1_(PAI-1)
gptkb:plasminogen_activator_inhibitor-2_(PAI-2)
|
|
gptkbp:InterPro
|
IPR001314
|
|
gptkbp:KEGGID
|
HSA:5328
|
|
gptkbp:locatedOnChromosome
|
gptkb:10q22.2
|
|
gptkbp:medicalUse
|
thrombolytic therapy
|
|
gptkbp:molecularWeight
|
~54 kDa
|
|
gptkbp:OMIM
|
191840
|
|
gptkbp:PDB
|
gptkb:1C5W
1F5L
1OWE
|
|
gptkbp:product
|
plasmin
|
|
gptkbp:proteinFamily
|
PF00089
|
|
gptkbp:recommendation
|
gptkb:urokinase
|
|
gptkbp:structure
|
single-chain and two-chain forms
|
|
gptkbp:substrate
|
gptkb:plasminogen
|
|
gptkbp:systematicName
|
gptkb:plasminogen:arginine-valine_ligase_(fibrinolysis-related)
|
|
gptkbp:UniProtID
|
gptkb:P00749
|
|
gptkbp:usedFor
|
treatment of deep vein thrombosis
treatment of pulmonary embolism
treatment of myocardial infarction
|
|
gptkbp:bfsParent
|
gptkb:PEP_family
|
|
gptkbp:bfsLayer
|
6
|