|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:activeSiteResidue
|
serine
|
|
gptkbp:CASNumber
|
9014-74-8
|
|
gptkbp:catalyzes
|
cleavage of trypsinogen
|
|
gptkbp:cleavage_site
|
Lys-Ile bond in trypsinogen
|
|
gptkbp:cofactor
|
none required
|
|
gptkbp:deficiencyCauses
|
protein malabsorption
|
|
gptkbp:discoveredBy
|
gptkb:Wilhelm_Kühne
|
|
gptkbp:discoveredIn
|
1902
|
|
gptkbp:EC_number
|
3.4.21.9
|
|
gptkbp:enzymeClassification
|
gptkb:serine_endopeptidase
|
|
gptkbp:foundIn
|
gptkb:duodenum
|
|
gptkbp:function
|
activates trypsinogen to trypsin
|
|
gptkbp:gene
|
TMPRSS15
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
enteropeptidase
|
|
gptkbp:inhibitedBy
|
gptkb:serine_protease_inhibitors
|
|
gptkbp:locale
|
brush border of small intestine
|
|
gptkbp:locatedOnChromosome
|
21q21
|
|
gptkbp:molecularWeight
|
~140 kDa
|
|
gptkbp:OMIM
|
606635
|
|
gptkbp:otherName
|
gptkb:enterokinase
|
|
gptkbp:PDB
|
4DGJ
|
|
gptkbp:producedBy
|
duodenal epithelial cells
|
|
gptkbp:role_in_digestion
|
initiates activation cascade of pancreatic proteases
|
|
gptkbp:significance
|
congenital enteropeptidase deficiency
|
|
gptkbp:species
|
found in humans
found in other vertebrates
|
|
gptkbp:structure
|
type II transmembrane serine protease
|
|
gptkbp:substrate
|
trypsinogen
|
|
gptkbp:UniProtID
|
Q90059
|
|
gptkbp:bfsParent
|
gptkb:trypsin
|
|
gptkbp:bfsLayer
|
6
|