|
gptkbp:instanceOf
|
gptkb:serine_protease
gptkb:enzyme
|
|
gptkbp:activatedBy
|
gptkb:factor_VIIIa
gptkb:factor_VIIa
gptkb:factor_IXa
|
|
gptkbp:biologicalProcess
|
endopeptidase activity
|
|
gptkbp:catalyzes
|
conversion of prothrombin to thrombin
|
|
gptkbp:cleavage
|
prothrombin
|
|
gptkbp:discoveredBy
|
20th century
|
|
gptkbp:EC_number
|
3.4.21.6
|
|
gptkbp:form
|
prothrombinase complex
|
|
gptkbp:formsComplexWith
|
gptkb:factor_Va
phospholipids
calcium ions
|
|
gptkbp:foundIn
|
blood plasma
|
|
gptkbp:gene
|
gptkb:F10
|
|
gptkbp:inhibitedBy
|
gptkb:rivaroxaban
gptkb:apixaban
gptkb:betrixaban
gptkb:edoxaban
gptkb:fondaparinux
gptkb:antithrombin_III
|
|
gptkbp:partOf
|
coagulation cascade
|
|
gptkbp:producedBy
|
activation of factor X
|
|
gptkbp:role
|
blood coagulation
|
|
gptkbp:significance
|
hemophilia
thrombosis
anticoagulation therapy
|
|
gptkbp:structure
|
heterodimer
|
|
gptkbp:target
|
anticoagulant drugs
|
|
gptkbp:bfsParent
|
gptkb:antithrombin
gptkb:tissue_factor_pathway_inhibitor
gptkb:Heparin
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
factor Xa
|