Statements (35)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:serine_protease
gptkb:enzyme |
| gptkbp:activatedBy |
gptkb:factor_VIIIa
gptkb:factor_VIIa gptkb:factor_IXa |
| gptkbp:biologicalProcess |
endopeptidase activity
|
| gptkbp:catalyzes |
conversion of prothrombin to thrombin
|
| gptkbp:cleavage |
prothrombin
|
| gptkbp:discoveredBy |
20th century
|
| gptkbp:EC_number |
3.4.21.6
|
| gptkbp:form |
prothrombinase complex
|
| gptkbp:formsComplexWith |
gptkb:factor_Va
phospholipids calcium ions |
| gptkbp:foundIn |
blood plasma
|
| gptkbp:gene |
gptkb:F10
|
| https://www.w3.org/2000/01/rdf-schema#label |
factor Xa
|
| gptkbp:inhibitedBy |
gptkb:rivaroxaban
gptkb:apixaban gptkb:betrixaban gptkb:edoxaban gptkb:fondaparinux gptkb:antithrombin_III |
| gptkbp:partOf |
coagulation cascade
|
| gptkbp:producedBy |
activation of factor X
|
| gptkbp:role |
blood coagulation
|
| gptkbp:significance |
hemophilia
thrombosis anticoagulation therapy |
| gptkbp:structure |
heterodimer
|
| gptkbp:target |
anticoagulant drugs
|
| gptkbp:bfsParent |
gptkb:factor_X
gptkb:Heparin gptkb:factor_II |
| gptkbp:bfsLayer |
6
|