|
gptkbp:instanceOf
|
gptkb:drug
antineoplastic agent
|
|
gptkbp:approvalYear
|
1969
|
|
gptkbp:ATCCode
|
L01XB01
|
|
gptkbp:CASNumber
|
366-70-1
|
|
gptkbp:chemicalFormula
|
C12H19N3O
|
|
gptkbp:contraindication
|
pregnancy
severe renal impairment
severe hepatic impairment
|
|
gptkbp:drugClass
|
antineoplastic agent
|
|
gptkbp:eliminationHalfLife
|
10 minutes
|
|
gptkbp:excretion
|
urine
|
|
gptkbp:genericName
|
gptkb:procarbazine
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Matulane
|
|
gptkbp:interactsWith
|
gptkb:beer
gptkb:tricyclic_antidepressants
gptkb:MAO_inhibitors
sympathomimetic drugs
|
|
gptkbp:legalStatus
|
prescription only
|
|
gptkbp:manufacturer
|
gptkb:Sigma-Tau_Pharmaceuticals
|
|
gptkbp:mechanismOfAction
|
antineoplastic agent
|
|
gptkbp:metabolism
|
liver
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:riskFactor
|
teratogenicity
carcinogenicity
mutagenicity
|
|
gptkbp:routeOfAdministration
|
oral
|
|
gptkbp:sideEffect
|
nausea
vomiting
neurotoxicity
thrombocytopenia
secondary malignancy
leukopenia
myelosuppression
|
|
gptkbp:synonym
|
Natulan
Procarbazine hydrochloride
|
|
gptkbp:UNII
|
S71QO7B19Q
|
|
gptkbp:usedFor
|
Hodgkin lymphoma
|
|
gptkbp:bfsParent
|
gptkb:procarbazine
|
|
gptkbp:bfsLayer
|
7
|