DB01168

GPTKB entity

Statements (58)
Predicate Object
gptkbp:instanceOf gptkb:drug
gptkbp:approvalYear 1994
gptkbp:ATCCode A10BA02
gptkbp:bioavailability 50-60%
gptkbp:brand gptkb:Diabex
gptkb:Diaformin
gptkb:Metfogamma
gptkb:Riomet
gptkb:Siofor
gptkb:Dianben
gptkb:Glifor
gptkb:Obimet
gptkb:Glucophage_XR
gptkb:Fortamet
gptkb:Glucophage
gptkb:Glumetza
gptkbp:CASNumber 657-24-9
gptkbp:contraindication renal impairment
hepatic impairment
acute or chronic metabolic acidosis
gptkbp:drugInteraction gptkb:beer
cimetidine
iodinated contrast agents
gptkbp:eliminationHalfLife 4-8.7 hours
gptkbp:excretion renal
gptkbp:form C4H11N5
gptkbp:genericAvailable yes
gptkbp:hasInChIKey gptkb:XZWYZXLIPXDOLR-UHFFFAOYSA-N
gptkbp:hasSMILES CN(C)C(=N)N=C(N)N
gptkbp:hasUNII 9100L32L2N
https://www.w3.org/2000/01/rdf-schema#label DB01168
gptkbp:indication gptkb:type_2_diabetes_mellitus
gptkb:polycystic_ovary_syndrome_(off-label)
gptkbp:isApprovedDrug gptkb:WHO_Model_List_of_Essential_Medicines
yes
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction decreases hepatic glucose production
increases insulin sensitivity
decreases intestinal absorption of glucose
gptkbp:metabolism not metabolized
gptkbp:molecularWeight 129.164
gptkbp:name gptkb:Metformin
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding negligible
gptkbp:PubChem_CID gptkb:DB01168
gptkb:CHEMBL1431
gptkb:D01841
4091
3949
gptkbp:routeOfAdministration oral
gptkbp:sideEffect nausea
diarrhea
abdominal pain
gastrointestinal upset
lactic acidosis
metallic taste
gptkbp:bfsParent gptkb:procarbazine
gptkbp:bfsLayer 7