plasminogen activator, tissue type

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:enzyme
gptkbp:alternativeName	gptkb:t-PA gptkb:tPA
gptkbp:discoveredBy	S. Astrup
gptkbp:discoveredIn	1947
gptkbp:domain	EGF-like domain serine protease domain finger domain kringle domain
gptkbp:EC_number	3.4.21.68
gptkbp:encodedBy	gptkb:PLAT_gene
gptkbp:Entrez_Gene_ID	gptkb:ENSG00000104368 5327 GC08P042073
gptkbp:expressedIn	gptkb:kidney brain liver
gptkbp:foundIn	blood plasma endothelial cells
gptkbp:function	fibrinolysis converts plasminogen to plasmin
gptkbp:gene	gptkb:PLAT
gptkbp:hasApprovedDrug	gptkb:alteplase gptkb:reteplase gptkb:tenecteplase
gptkbp:HGNC_ID	gptkb:HGNC:9051
gptkbp:inhibitedBy	gptkb:plasminogen_activator_inhibitor-1 plasminogen activator inhibitor-2
gptkbp:locatedOnChromosome	chromosome 8p11.21
gptkbp:medicalUse	myocardial infarction pulmonary embolism acute ischemic stroke
gptkbp:molecularWeight	~70 kDa
gptkbp:OMIM	173370
gptkbp:orthologIn	gptkb:Bos_taurus gptkb:Mus_musculus gptkb:Rattus_norvegicus
gptkbp:PDB	gptkb:1BDA
gptkbp:RefSeq	gptkb:NM_000930
gptkbp:relatedTo	gptkb:urokinase-type_plasminogen_activator gptkb:fibrin thrombolysis
gptkbp:species	gptkb:Homo_sapiens
gptkbp:structure	gptkb:serine_protease
gptkbp:UniProtID	P00750
gptkbp:usedAs	thrombolytic drug
gptkbp:bfsParent	gptkb:PLAT
gptkbp:bfsLayer	7
https://www.w3.org/2000/01/rdf-schema#label	plasminogen activator, tissue type