plasminogen activator, tissue type

URI: https://gptkb.org/entity/plasminogen_activator,_tissue_type
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alternativeName gptkb:t-PA
gptkb:tPA
gptkbp:discoveredBy S. Astrup
gptkbp:discoveredIn 1947
gptkbp:domain EGF-like domain
serine protease domain
finger domain
kringle domain
gptkbp:EC_number 3.4.21.68
gptkbp:encodedBy gptkb:PLAT_gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000104368
5327
GC08P042073
gptkbp:expressedIn gptkb:kidney
brain
liver
gptkbp:foundIn blood plasma
endothelial cells
gptkbp:function fibrinolysis
converts plasminogen to plasmin
gptkbp:gene gptkb:PLAT
gptkbp:hasApprovedDrug gptkb:alteplase
gptkb:reteplase
gptkb:tenecteplase
gptkbp:HGNC_ID gptkb:HGNC:9051
https://www.w3.org/2000/01/rdf-schema#label plasminogen activator, tissue type
gptkbp:inhibitedBy gptkb:plasminogen_activator_inhibitor-1
plasminogen activator inhibitor-2
gptkbp:locatedOnChromosome chromosome 8p11.21
gptkbp:medicalUse myocardial infarction
pulmonary embolism
acute ischemic stroke
gptkbp:molecularWeight ~70 kDa
gptkbp:OMIM 173370
gptkbp:orthologIn gptkb:Bos_taurus
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB gptkb:1BDA
gptkbp:RefSeq gptkb:NM_000930
gptkbp:relatedTo gptkb:urokinase-type_plasminogen_activator
gptkb:fibrin
thrombolysis
gptkbp:species gptkb:Homo_sapiens
gptkbp:structure gptkb:serine_protease
gptkbp:UniProtID P00750
gptkbp:usedAs thrombolytic drug
gptkbp:bfsParent gptkb:PLAT
gptkbp:bfsLayer 7