|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:PLAT
gptkb:tPA
Tissue-type plasminogen activator
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
myocardial infarction
stroke
thrombolytic therapy
|
|
gptkbp:discoveredBy
|
S. Chibber et al.
|
|
gptkbp:encodes
|
gptkb:tissue_plasminogen_activator
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000104368
5327
|
|
gptkbp:expressedIn
|
endothelial cells
|
|
gptkbp:function
|
fibrinolysis
serine-type endopeptidase activity
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:9051
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PLAT gene
|
|
gptkbp:length
|
approximately 32 kb
|
|
gptkbp:locatedOnChromosome
|
gptkb:8p11.21
chromosome 8
|
|
gptkbp:medicalUse
|
recombinant tPA used in thrombolytic therapy
|
|
gptkbp:mutationAssociatedWith
|
may increase risk of thrombosis
may affect fibrinolytic activity
|
|
gptkbp:numberOfExons
|
14
|
|
gptkbp:OMIM
|
173370
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Plat
|
|
gptkbp:product
|
gptkb:tPA
|
|
gptkbp:UniProtID
|
P00750
|
|
gptkbp:bfsParent
|
gptkb:tissue_plasminogen_activator
|
|
gptkbp:bfsLayer
|
7
|