|
gptkbp:instanceOf
|
gptkb:protein
gptkb:enzyme
|
|
gptkbp:CASNumber
|
105857-23-6
|
|
gptkbp:category
|
gptkb:tissue_plasminogen_activator
gptkb:serine_protease
|
|
gptkbp:contraindication
|
active internal bleeding
history of hemorrhagic stroke
|
|
gptkbp:discoveredBy
|
gptkb:S._Sherry
|
|
gptkbp:discoveredIn
|
1980
|
|
gptkbp:EC_number
|
3.4.21.68
|
|
gptkbp:expressedIn
|
brain
liver
endothelial cells
|
|
gptkbp:fullName
|
gptkb:tissue_plasminogen_activator
|
|
gptkbp:function
|
catalyzes conversion of plasminogen to plasmin
|
|
gptkbp:gene
|
gptkb:PLAT
|
|
gptkbp:halfLife
|
~5 minutes
|
|
gptkbp:hasApprovedDrug
|
gptkb:alteplase
gptkb:reteplase
gptkb:tenecteplase
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
t-PA
|
|
gptkbp:locatedOnChromosome
|
gptkb:8p11.21
|
|
gptkbp:marketedAs
|
gptkb:Boehringer_Ingelheim
gptkb:Genentech
gptkb:Roche
|
|
gptkbp:mechanismOfAction
|
fibrinolysis
|
|
gptkbp:molecularWeight
|
~70 kDa
|
|
gptkbp:orthologIn
|
gptkb:urokinase
|
|
gptkbp:PDB
|
gptkb:1TPA
|
|
gptkbp:producedBy
|
endothelial cells
|
|
gptkbp:product
|
plasmin
|
|
gptkbp:recombinantForm
|
gptkb:alteplase
gptkb:reteplase
gptkb:tenecteplase
|
|
gptkbp:regulates
|
inhibited by PAI-1
inhibited by alpha-2-antiplasmin
|
|
gptkbp:riskFactor
|
bleeding
|
|
gptkbp:routeOfAdministration
|
intravenous
|
|
gptkbp:sideEffect
|
allergic reaction
hypotension
intracranial hemorrhage
|
|
gptkbp:structureType
|
gptkb:protein
|
|
gptkbp:substrate
|
gptkb:plasminogen
|
|
gptkbp:UniProtID
|
P00750
|
|
gptkbp:usedFor
|
treatment of pulmonary embolism
treatment of ischemic stroke
treatment of myocardial infarction
|
|
gptkbp:usedIn
|
thrombolytic therapy
|
|
gptkbp:bfsParent
|
gptkb:PLAT
|
|
gptkbp:bfsLayer
|
7
|