urokinase-type plasminogen activator

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:enzyme
gptkbp:alsoKnownAs	gptkb:uPA
gptkbp:CASNumber	9039-53-6
gptkbp:category	serine proteases fibrinolytic agents
gptkbp:cleavage	plasmin
gptkbp:clinicalTrialPhase	used in stroke therapy trials
gptkbp:discoveredBy	1960s
gptkbp:EC_number	3.4.21.73
gptkbp:expressedIn	gptkb:kidney liver macrophages endothelial cells tumor cells
gptkbp:foundIn	humans other mammals
gptkbp:function	converts plasminogen to plasmin
gptkbp:gene	gptkb:PLAU
gptkbp:GO_term	GO:0004252
https://www.w3.org/2000/01/rdf-schema#label	urokinase-type plasminogen activator
gptkbp:inhibitedBy	gptkb:PAI-1 PAI-2
gptkbp:involvedIn	fibrinolysis
gptkbp:locatedOnChromosome	gptkb:10q22.2
gptkbp:medicalUse	gptkb:tissue_plasminogen_activator
gptkbp:molecularWeight	33 kDa (two-chain form) 54 kDa (single chain)
gptkbp:OMIM	191840
gptkbp:orthologIn	tissue-type plasminogen activator (tPA)
gptkbp:PDB	1OWE
gptkbp:producedBy	macrophages endothelial cells kidney cells
gptkbp:recipient	uPAR
gptkbp:regulates	upregulated by cytokines inhibited by PAI-1 inhibited by PAI-2
gptkbp:role	thrombosis cancer metastasis fibrinolytic disorders
gptkbp:structure	gptkb:serine_protease
gptkbp:substrate	gptkb:plasminogen
gptkbp:UniProtID	gptkb:P00749
gptkbp:usedIn	treatment of deep vein thrombosis treatment of pulmonary embolism treatment of myocardial infarction catheter clearance
gptkbp:bfsParent	gptkb:EC_3.4.21.26 gptkb:1HUR gptkb:PLAU
gptkbp:bfsLayer	7