alteplase

GPTKB entity

Statements (51)
Predicate Object
gptkbp:instanceOf gptkb:tissue_plasminogen_activator
gptkb:drug
gptkbp:administrationTimeWindow within 3-4.5 hours of stroke onset
gptkbp:approvedBy gptkb:FDA
gptkb:EMA
1987
gptkbp:ATCCode B01AD02
gptkbp:bioavailability 100% (IV)
gptkbp:brand gptkb:Activase
gptkb:Actilyse
gptkbp:CASNumber 105857-23-6
gptkbp:category gptkb:tissue_plasminogen_activator
fibrinolytic drug
gptkbp:chemicalFormula C2569H3928N746O781S40
gptkbp:compatibleWith hemorrhagic stroke
gptkbp:contraindication active internal bleeding
history of hemorrhagic stroke
gptkbp:cost expensive
gptkbp:developedBy gptkb:Genentech
gptkbp:eliminationHalfLife 4-6 minutes
gptkbp:excretion urine
gptkbp:foundIn hospital formulary
https://www.w3.org/2000/01/rdf-schema#label alteplase
gptkbp:legalStatus prescription only
gptkbp:mechanismOfAction converts plasminogen to plasmin
gptkbp:metabolism hepatic
gptkbp:molecularWeight 59,050 Da
gptkbp:monitors gptkb:neuroscientist
emergency physician
gptkbp:origin recombinant DNA technology
gptkbp:pregnancyCategory C (US)
B3 (Australia)
gptkbp:prescribes gptkb:physician
gptkbp:product gptkb:protein
gptkbp:requiresMonitoring coagulation parameters
neurological status
gptkbp:riskFactor intracranial hemorrhage
gptkbp:routeOfAdministration intravenous
gptkbp:sideEffect bleeding
allergic reaction
gptkbp:storage refrigerated
gptkbp:synonym gptkb:rtPA
recombinant tissue plasminogen activator
gptkbp:target gptkb:plasminogen
gptkbp:UNII QGJ20R72FS
gptkbp:usedFor myocardial infarction
pulmonary embolism
acute ischemic stroke
gptkbp:WHOModelListOfEssentialMedicines included
gptkbp:bfsParent gptkb:Activase
gptkbp:bfsLayer 6