phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

URI: https://gptkb.org/entity/phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_alpha
GPTKB entity
Statements (32)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:PI3-kinase_p110_alpha
gptkb:PIK3CA_protein
gptkbp:associatedWith gptkb:cancer
gptkb:endometrial_cancer
colorectal cancer
gptkbp:biologicalProcess kinase activity
gptkbp:discoveredBy 1990s
gptkbp:enzymeCommissionNumber 2.7.1.153
gptkbp:function catalyzes phosphorylation of phosphatidylinositol-4,5-bisphosphate
involved in PI3K/AKT signaling pathway
gptkbp:gene gptkb:PIK3CA
https://www.w3.org/2000/01/rdf-schema#label phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
gptkbp:inhibitedBy gptkb:alpelisib
gptkb:wortmannin
gptkb:BYL719
gptkbp:interactsWith regulatory subunit p85
gptkbp:length 1068
gptkbp:locatedOnChromosome 3q26.32
gptkbp:location gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:molecularWeight 124 kDa
gptkbp:mutationAssociatedWith oncogenic
gptkbp:organism gptkb:Homo_sapiens
gptkbp:PDB 4OVV
gptkbp:phosphorylates phosphatidylinositol-4,5-bisphosphate
gptkbp:product phosphatidylinositol-3,4,5-trisphosphate
gptkbp:subunit gptkb:phosphoinositide_3-kinase_complex
gptkbp:UniProtID gptkb:P42336
gptkbp:bfsParent gptkb:PI3KCA
gptkb:PIK3CA_(p110α)
gptkbp:bfsLayer 6