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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alternativeName
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gptkb:p110α
gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_alpha_isoform
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gptkbp:biologicalProcess
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kinase activity
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gptkbp:component
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gptkb:phosphoinositide_3-kinase_(PI3K)_complex
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gptkbp:encodedBy
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gptkb:PIK3CA_gene
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gptkbp:function
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catalyzes phosphorylation of phosphatidylinositol-4,5-bisphosphate (PIP2) to phosphatidylinositol-3,4,5-trisphosphate (PIP3)
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https://www.w3.org/2000/01/rdf-schema#label
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PIK3CA protein
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gptkbp:interactsWith
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gptkb:RAS_protein
PIK3R1 protein
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gptkbp:involvedIn
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gptkb:PI3K/AKT_signaling_pathway
cell proliferation
cell survival
cell growth regulation
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gptkbp:locatedOnChromosome
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3q26.32
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gptkbp:location
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gptkb:cytoplasm
gptkb:plasma_membrane
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gptkbp:mutationAssociatedWith
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gptkb:cancer
gptkb:endometrial_cancer
gptkb:glioblastoma
colorectal cancer
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gptkbp:postTranslationalModification
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phosphorylation
ubiquitination
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gptkbp:species
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gptkb:Homo_sapiens
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gptkbp:target
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gptkb:alpelisib
PI3K inhibitors
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gptkbp:UniProtID
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gptkb:P42336
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gptkbp:bfsParent
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gptkb:phosphatidylinositol-4,5-bisphosphate_3-kinase_catalytic_subunit_alpha_isoform
gptkb:PI3K-alpha
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gptkbp:bfsLayer
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6
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