|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:GSK-3_beta
gptkb:glycogen_synthase_kinase-3_beta
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
gptkb:diabetes_mellitus
bipolar disorder
|
|
gptkbp:discoveredIn
|
1990
|
|
gptkbp:EC_number
|
2.7.11.26
|
|
gptkbp:Entrez_Gene_ID
|
56637
ENSMUSG00000021987
|
|
gptkbp:expressedIn
|
ubiquitous
|
|
gptkbp:fullName
|
glycogen synthase kinase 3 beta
|
|
gptkbp:function
|
gptkb:Wnt_signaling_pathway
apoptosis
cell differentiation
insulin signaling pathway
serine/threonine protein kinase
regulation of glycogen metabolism
|
|
gptkbp:gene
|
gptkb:Gsk3b
|
|
gptkbp:GO_term
|
gptkb:GO:0004674
GO:0005524
GO:0006468
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
mouse Gsk3b
|
|
gptkbp:inhibitedBy
|
gptkb:SB-216763
gptkb:CHIR99021
gptkb:lithium_chloride
AR-A014418
|
|
gptkbp:locatedOnChromosome
|
16
|
|
gptkbp:molecularWeight
|
47 kDa
|
|
gptkbp:organism
|
gptkb:Mus_musculus
|
|
gptkbp:orthologIn
|
gptkb:rat_Gsk3b
human GSK3B
|
|
gptkbp:pathway
|
KEGG:mmu04151 (PI3K-Akt signaling pathway)
KEGG:mmu04310 (Wnt signaling pathway)
KEGG:mmu04910 (Insulin signaling pathway)
|
|
gptkbp:phosphorylates
|
autophosphorylation
Ser9
Tyr216
|
|
gptkbp:proteinFamily
|
CMGC kinase family
|
|
gptkbp:RefSeq
|
NM_019827
|
|
gptkbp:regulates
|
activated by phosphorylation at Tyr216
inhibited by phosphorylation at Ser9
|
|
gptkbp:relatedHumanGene
|
gptkb:GSK3B
|
|
gptkbp:structure
|
contains a kinase domain
|
|
gptkbp:subcellularLocation
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:UniProtID
|
Q9WV60
|
|
gptkbp:bfsParent
|
gptkb:GSK3β
|
|
gptkbp:bfsLayer
|
7
|