|
gptkbp:instance_of
|
gptkb:pharmaceuticals
|
|
gptkbp:approves
|
1953
|
|
gptkbp:brand
|
gptkb:Rheumatrex
gptkb:Otrexup
Xatmep
|
|
gptkbp:category
|
gptkb:X
|
|
gptkbp:class
|
gptkb:immunotherapy
gptkb:oppression
|
|
gptkbp:contraindication
|
alcohol consumption
pregnancy
|
|
gptkbp:dosage_form
|
10 mg
oral tablet
50 mg
15 mg
25 mg
2.5 mg
|
|
gptkbp:formulation
|
gptkb:tablet
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Trexall
|
|
gptkbp:ingredients
|
gptkb:methotrexate
|
|
gptkbp:interacts_with
|
NSAIDs
antibiotics
live vaccines
sulfonamides
|
|
gptkbp:is_monitored_by
|
liver function tests
complete blood count
renal function tests
|
|
gptkbp:lifespan
|
8 to 15 hours
|
|
gptkbp:manufacturer
|
various pharmaceutical companies
|
|
gptkbp:mechanism_of_action
|
inhibits dihydrofolate reductase
|
|
gptkbp:metabolism
|
hepatic
|
|
gptkbp:patient_education
|
avoid alcohol
stay hydrated
report signs of infection
regular blood tests required
|
|
gptkbp:requires
|
prescription only
|
|
gptkbp:rounds
|
renal
|
|
gptkbp:route_of_administration
|
oral
|
|
gptkbp:side_effect
|
fatigue
nausea
liver toxicity
mouth sores
|
|
gptkbp:storage
|
room temperature
|
|
gptkbp:structure
|
C20 H22 N8 O5
|
|
gptkbp:used_for
|
treatment of psoriasis
treatment of rheumatoid arthritis
|
|
gptkbp:bfsParent
|
gptkb:methotrexate
|
|
gptkbp:bfsLayer
|
5
|