Statements (56)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
cytokine
|
| gptkbp:abbreviation |
gptkb:LIF
|
| gptkbp:discoveredBy |
1988
|
| gptkbp:Entrez_Gene_ID |
GC22M030282
|
| gptkbp:foundIn |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:function |
regulation of cell differentiation
modulation of immune response maintenance of embryonic stem cell pluripotency inhibition of differentiation in mouse embryonic stem cells stimulation of acute phase protein synthesis |
| gptkbp:gene |
gptkb:LIF_gene
gptkb:LIF |
| gptkbp:HGNC_ID |
6596
|
| https://www.w3.org/2000/01/rdf-schema#label |
leukemia inhibitory factor
|
| gptkbp:inducedBy |
differentiation of myeloid leukemic cells
|
| gptkbp:inhibitedBy |
adipogenesis
muscle cell differentiation differentiation of embryonic stem cells myeloid leukemia cell proliferation |
| gptkbp:involves |
neural development
bone metabolism inflammatory response muscle regeneration implantation in mammals |
| gptkbp:locatedOnChromosome |
22q12.2
|
| gptkbp:member |
gptkb:interleukin-6_family
|
| gptkbp:molecularWeight |
~20 kDa
|
| gptkbp:OMIM |
159540
|
| gptkbp:pathway |
gptkb:MAPK_pathway
gptkb:PI3K/AKT_pathway gptkb:JAK/STAT_pathway |
| gptkbp:producedBy |
gptkb:T_cells
macrophages fibroblasts endometrial cells |
| gptkbp:promotion |
neurite outgrowth
acute phase response adipocyte differentiation astrocyte differentiation cholinergic differentiation hepatocyte acute phase protein synthesis megakaryocyte maturation myoblast proliferation osteoclast formation |
| gptkbp:recipient |
gptkb:gp130
gptkb:LIF_receptor |
| gptkbp:significance |
gptkb:cancer
neurodegenerative diseases inflammatory diseases infertility |
| gptkbp:structure |
gptkb:protein
|
| gptkbp:UniProtID |
gptkb:P15018
|
| gptkbp:used_in |
stem cell culture
|
| gptkbp:bfsParent |
gptkb:gp130_receptor
|
| gptkbp:bfsLayer |
6
|