|
gptkbp:instanceOf
|
cytokine
|
|
gptkbp:alternativeName
|
gptkb:cytokine_synthesis_inhibitory_factor
|
|
gptkbp:associatedWith
|
gptkb:systemic_lupus_erythematosus
asthma
psoriasis
rheumatoid arthritis
inflammatory bowel disease
|
|
gptkbp:discoveredBy
|
1989
|
|
gptkbp:Entrez_Gene_ID
|
3586
ENSG00000136634
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:placenta
liver
lymph nodes
spleen
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
anti-inflammatory cytokine
|
|
gptkbp:gene
|
gptkb:IL10
|
|
gptkbp:HGNC_ID
|
5962
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
interleukin-10
|
|
gptkbp:inhibitedBy
|
IFN-gamma production
GM-CSF production
IL-1 production
IL-2 production
IL-6 production
TNF-alpha production
synthesis of pro-inflammatory cytokines
|
|
gptkbp:involves
|
immune tolerance
inhibition of antigen presentation
regulation of JAK-STAT signaling pathway
|
|
gptkbp:locatedOnChromosome
|
1q32.1
|
|
gptkbp:molecularWeight
|
~18 kDa (monomer)
|
|
gptkbp:OMIM
|
124092
|
|
gptkbp:PDB
|
2ILK
|
|
gptkbp:producedBy
|
gptkb:B_cells
gptkb:T_cells
macrophages
monocytes
|
|
gptkbp:promotion
|
B cell proliferation
antibody production
|
|
gptkbp:recipient
|
gptkb:interleukin-10_receptor
|
|
gptkbp:regulates
|
immune response
Th1/Th2 balance
|
|
gptkbp:structure
|
homodimer
|
|
gptkbp:suppressedBy
|
antigen presentation
macrophage activation
dendritic cell function
|
|
gptkbp:symbol
|
gptkb:IL-10
|
|
gptkbp:UniProtID
|
gptkb:P22301
|
|
gptkbp:usedFor
|
autoimmune diseases (experimental)
|
|
gptkbp:bfsParent
|
gptkb:Cytokine_Release_Syndrome
gptkb:T_helper_2_cells
|
|
gptkbp:bfsLayer
|
7
|