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gptkbp:instanceOf
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gptkb:protein
gptkb:gene
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gptkbp:alternativeName
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gptkb:Cation-independent_mannose-6-phosphate_receptor
gptkb:Insulin-like_growth_factor_2_receptor
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gptkbp:discoveredBy
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Willy J. M. van den Berghe (mannose-6-phosphate receptor)
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gptkbp:domain
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IGF2 binding domain
mannose-6-phosphate binding domain
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gptkbp:encodedBy
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gptkb:IGF2R_gene
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gptkbp:expressedIn
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many tissues
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gptkbp:foundIn
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gptkb:Homo_sapiens
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gptkbp:function
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binds IGF2
traffics lysosomal enzymes
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gptkbp:HGNC_ID
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gptkb:HGNC:5444
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https://www.w3.org/2000/01/rdf-schema#label
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IGF2 receptor
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gptkbp:interactsWith
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gptkb:IGF2
mannose-6-phosphate-containing proteins
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gptkbp:locatedOnChromosome
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chromosome 6q25.3
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gptkbp:location
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gptkb:endosome
gptkb:cell_membrane
gptkb:Golgi_apparatus
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gptkbp:molecularWeight
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~300 kDa
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gptkbp:mutationAssociatedWith
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gptkb:cancer
growth disorders
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gptkbp:OMIM
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147280
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gptkbp:orthologIn
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gptkb:Mus_musculus
gptkb:Rattus_norvegicus
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gptkbp:role
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tumor suppression
lysosomal enzyme targeting
regulation of IGF2 availability
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gptkbp:structure
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single-pass type I membrane protein
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gptkbp:UniProtID
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P11717
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gptkbp:bfsParent
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gptkb:IGF2
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gptkbp:bfsLayer
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6
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