human beta-2 adrenergic receptor

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein gptkb:G_protein-coupled_receptor
gptkbp:alternativeName	gptkb:ADRB2 gptkb:beta-2_adrenoceptor gptkb:beta-2_adrenergic_receptor β2AR
gptkbp:associatedWith	asthma heart failure hypertension chronic obstructive pulmonary disease
gptkbp:discoveredBy	gptkb:Robert_Lefkowitz
gptkbp:drugClass	adrenergic receptor
gptkbp:encodedBy	gptkb:ADRB2_gene
gptkbp:enemyOf	gptkb:salbutamol gptkb:albuterol propranolol terbutaline ICI 118,551 butoxamine
gptkbp:Entrez_Gene_ID	154
gptkbp:expressedIn	gptkb:cancer gptkb:skeletal_muscle heart liver vascular smooth muscle
gptkbp:family	rhodopsin-like GPCR
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	increases heart rate mediates effects of epinephrine and norepinephrine regulates smooth muscle relaxation involved in bronchodilation
https://www.w3.org/2000/01/rdf-schema#label	human beta-2 adrenergic receptor
gptkbp:length	413
gptkbp:ligand	norepinephrine epinephrine
gptkbp:locatedIn	gptkb:cell_membrane
gptkbp:locatedOnChromosome	5q31-q32
gptkbp:molecularWeight	46 kDa
gptkbp:mutationAssociatedWith	altered drug response increased risk of asthma exacerbations
gptkbp:OMIM	109690
gptkbp:PDB	gptkb:2RH1
gptkbp:postTranslationalModification	phosphorylation glycosylation
gptkbp:significance	target for COPD drugs target for asthma drugs
gptkbp:structureType	seven transmembrane domains
gptkbp:type	activates adenylate cyclase via Gs protein
gptkbp:UniProtID	gptkb:P07550
gptkbp:bfsParent	gptkb:1JM7
gptkbp:bfsLayer	7