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gptkbp:instanceOf
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gptkb:gene
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gptkbp:alternativeName
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ADRBR2 gene
B2AR gene
beta-2 adrenergic receptor gene
beta-2 adrenoceptor gene
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gptkbp:associatedWith
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asthma
heart failure
obesity
hypertension
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gptkbp:biologicalProcess
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gptkb:G_protein-coupled_receptor
regulates smooth muscle relaxation
involved in bronchodilation
involved in vasodilation
mediates catecholamine-induced activation of adenylate cyclase
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gptkbp:discoveredBy
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gptkb:Robert_Lefkowitz
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gptkbp:discoveredIn
|
1986
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gptkbp:encodes
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Beta-2 adrenergic receptor
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gptkbp:Entrez_Gene_ID
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gptkb:ENSG00000169252
154
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gptkbp:expressedIn
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gptkb:cancer
gptkb:skeletal_muscle
heart
liver
vascular smooth muscle
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gptkbp:geneType
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protein-coding
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gptkbp:hasPolymorphism
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gptkb:Arg16Gly
gptkb:Gln27Glu
gptkb:Thr164Ile
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gptkbp:HGNC_ID
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gptkb:HGNC:286
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|
https://www.w3.org/2000/01/rdf-schema#label
|
ADRB2 gene
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gptkbp:locatedOnChromosome
|
gptkb:chromosome_5
5q31-q32
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gptkbp:OMIM
|
109690
|
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gptkbp:orthologInMouse
|
gptkb:Adrb2
|
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gptkbp:regulates
|
lipolysis
cardiac output
glycogenolysis
airway smooth muscle tone
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gptkbp:targetOfDrug
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gptkb:formoterol
gptkb:salmeterol
gptkb:albuterol
gptkb:metoprolol
gptkb:carvedilol
gptkb:isoproterenol
propranolol
terbutaline
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gptkbp:UniProtID
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gptkb:P07550
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gptkbp:bfsParent
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gptkb:beta-adrenergic_receptor
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gptkbp:bfsLayer
|
6
|