|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:MMAC1
gptkb:TEP1
|
|
gptkbp:discoveredBy
|
gptkb:Peter_C._Steck
gptkb:Charis_Eng
|
|
gptkbp:discoveredIn
|
1997
|
|
gptkbp:encodedBy
|
gptkb:PTEN_gene
|
|
gptkbp:Entrez_Gene_ID
|
5728
|
|
gptkbp:enzymeCommissionNumber
|
3.1.3.67
|
|
gptkbp:expressedIn
|
many tissues
|
|
gptkbp:fullName
|
gptkb:Phosphatase_and_tensin_homolog
|
|
gptkbp:function
|
tumor suppressor
protein tyrosine phosphatase activity
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
|
|
gptkbp:gene
|
gptkb:PTEN
|
|
gptkbp:HGNC_ID
|
9588
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
human PTEN
|
|
gptkbp:inhibitedBy
|
gptkb:PI3K/AKT_signaling_pathway
|
|
gptkbp:length
|
403 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:10q23.3
|
|
gptkbp:location
|
gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
47 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Bannayan–Riley–Ruvalcaba_syndrome
gptkb:cancer
gptkb:Cowden_syndrome
gptkb:glioblastoma
prostate cancer
|
|
gptkbp:OMIM
|
601728
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:1D5R
gptkb:5BUG
|
|
gptkbp:postTranslationalModification
|
phosphorylation
oxidation
ubiquitination
acetylation
|
|
gptkbp:RefSeq
|
NP_000305.3
|
|
gptkbp:regulates
|
apoptosis
cell proliferation
cell survival
cell migration
cell cycle
|
|
gptkbp:requires
|
embryonic development
DNA repair
genome stability
|
|
gptkbp:structure
|
C2 domain
phosphatase domain
|
|
gptkbp:UniProtID
|
gptkb:P60484
|
|
gptkbp:bfsParent
|
gptkb:mouse_Pten
gptkb:zebrafish_ptena
gptkb:zebrafish_ptenb
|
|
gptkbp:bfsLayer
|
7
|