Phosphatase and tensin homolog

URI: https://gptkb.org/entity/Phosphatase_and_tensin_homolog
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
tumor suppressor
gptkbp:abbreviation gptkb:PTEN
gptkbp:alias gptkb:MMAC1
gptkb:TEP1
gptkbp:discoveredBy gptkb:Peter_C._Steck
gptkb:Paula_S._Meltzer
gptkbp:discoveredIn 1997
gptkbp:domain C2 domain
phosphatase domain
gptkbp:encodedBy gptkb:PTEN_gene
gptkbp:Entrez_Gene_ID 5728
gptkbp:enzymeCommissionNumber 3.1.3.67
gptkbp:expressedIn many tissues
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function phosphatase activity
lipid phosphatase
https://www.w3.org/2000/01/rdf-schema#label Phosphatase and tensin homolog
gptkbp:inhibitedBy gptkb:PI3K_pathway
gptkbp:involvedIn metabolism
angiogenesis
tumorigenesis
cellular signaling
genomic stability
gptkbp:locatedOnChromosome gptkb:10q23.3
gptkbp:location gptkb:cell_membrane
gptkb:nucleus
gptkb:cytoplasm
gptkbp:lossOfFunctionLeadsTo uncontrolled cell growth
gptkbp:molecularWeight 47 kDa
gptkbp:mutationAssociatedWith gptkb:Bannayan–Riley–Ruvalcaba_syndrome
gptkb:Lhermitte–Duclos_disease
gptkb:cancer
gptkb:Cowden_syndrome
gptkbp:OMIM 601728
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Caenorhabditis_elegans
gptkb:Drosophila_melanogaster
gptkbp:regulates gptkb:PI3K/AKT_signaling_pathway
apoptosis
cell survival
cell migration
cell cycle
gptkbp:substrate gptkb:phosphatidylinositol_(3,4,5)-trisphosphate
gptkbp:target post-translational modifications
microRNAs
gptkbp:UniProtID gptkb:P60484
gptkbp:bfsParent gptkb:P60484
gptkbp:bfsLayer 6