Phosphatase and tensin homolog

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:tumor_suppressor gptkb:protein
gptkbp:abbreviation	gptkb:PTEN
gptkbp:alias	gptkb:MMAC1 gptkb:TEP1
gptkbp:discoveredBy	gptkb:Peter_C._Steck gptkb:Paula_S._Meltzer
gptkbp:discoveredIn	1997
gptkbp:domain	C2 domain phosphatase domain
gptkbp:encodedBy	gptkb:PTEN_gene
gptkbp:Entrez_Gene_ID	5728
gptkbp:enzymeCommissionNumber	3.1.3.67
gptkbp:expressedIn	many tissues
gptkbp:foundIn	gptkb:Homo_sapiens
gptkbp:function	phosphatase activity lipid phosphatase
gptkbp:inhibitedBy	gptkb:PI3K_pathway
gptkbp:involvedIn	metabolism angiogenesis tumorigenesis cellular signaling genomic stability
gptkbp:locatedOnChromosome	gptkb:10q23.3
gptkbp:location	gptkb:cell_membrane gptkb:nucleus gptkb:cytoplasm
gptkbp:lossOfFunctionLeadsTo	uncontrolled cell growth
gptkbp:molecularWeight	47 kDa
gptkbp:mutationAssociatedWith	gptkb:Bannayan–Riley–Ruvalcaba_syndrome gptkb:Lhermitte–Duclos_disease gptkb:cancer gptkb:Cowden_syndrome
gptkbp:OMIM	601728
gptkbp:orthologIn	gptkb:Mus_musculus gptkb:Caenorhabditis_elegans gptkb:Drosophila_melanogaster
gptkbp:regulates	gptkb:PI3K/AKT_signaling_pathway apoptosis cell survival cell migration cell cycle
gptkbp:substrate	gptkb:phosphatidylinositol_(3,4,5)-trisphosphate
gptkbp:target	post-translational modifications microRNAs
gptkbp:UniProtID	gptkb:P60484
gptkbp:bfsParent	gptkb:P60484
gptkbp:bfsLayer	6
http://www.w3.org/2000/01/rdf-schema#label	Phosphatase and tensin homolog