|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alias
|
gptkb:5-HTT
gptkb:SERT
|
|
gptkbp:associatedWith
|
gptkb:depression
gptkb:autism_spectrum_disorder
gptkb:obsessive-compulsive_disorder
anxiety
|
|
gptkbp:biologicalProcess
|
synaptic transmission
serotonin uptake
serotonin:sodium symporter activity
|
|
gptkbp:cellularComponent
|
integral component of plasma membrane
|
|
gptkbp:chromosomeArm
|
q
|
|
gptkbp:discoveredIn
|
1993
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000108576
6532
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:placenta
brain
intestine
|
|
gptkbp:fullName
|
gptkb:solute_carrier_family_6_member_4
|
|
gptkbp:function
|
gptkb:serotonin_transporter
|
|
gptkbp:gene
|
gptkb:SLC6A4
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPolymorphism
|
gptkb:5-HTTLPR
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:11050
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
hsa:6513
|
|
gptkbp:length
|
630 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q11.2
17
|
|
gptkbp:location
|
gptkb:plasma_membrane
|
|
gptkbp:molecularWeight
|
70 kDa
|
|
gptkbp:mutationAssociatedWith
|
affects serotonin reuptake
|
|
gptkbp:OMIM
|
182138
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Slc6a4
gptkb:rat_Slc6a4
|
|
gptkbp:pathway
|
neuroactive ligand-receptor interaction
serotonergic synapse
antidepressant pharmacodynamics
|
|
gptkbp:proteinFamily
|
gptkb:solute_carrier_family
|
|
gptkbp:publicTransit
|
neurotransmitter transporter
|
|
gptkbp:referenceGenome
|
gptkb:GRCh38
|
|
gptkbp:substrate
|
serotonin
|
|
gptkbp:targetOfDrug
|
gptkb:tricyclic_antidepressants
gptkb:SSRIs
|
|
gptkbp:UniProtID
|
gptkb:P31645
|
|
gptkbp:bfsParent
|
gptkb:Glucose_transporter_type_1
|
|
gptkbp:bfsLayer
|
8
|