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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alias
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gptkb:HNRPA1
hnRNP core protein A1
heterogeneous nuclear ribonucleoprotein core protein A1
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gptkbp:alternativeSplicing
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produces isoforms A1-A and A1-B
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gptkbp:associatedWith
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gptkb:cancer
amyotrophic lateral sclerosis
multiple sclerosis
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gptkbp:discoveredBy
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gptkb:Dreyfuss_laboratory
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gptkbp:domain
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glycine-rich domain
RNA recognition motif (RRM)
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gptkbp:Entrez_Gene_ID
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ENSG00000135486
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gptkbp:fullName
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gptkb:Heterogeneous_nuclear_ribonucleoprotein_A1
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gptkbp:function
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RNA binding
mRNA stability
mRNA transport
alternative splicing regulation
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gptkbp:gene
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gptkb:HNRNPA1
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gptkbp:GO_term
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GO:0005737 (cytoplasm)
GO:0005634 (nucleus)
GO:0003723 (RNA binding)
GO:0008380 (RNA splicing)
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https://www.w3.org/2000/01/rdf-schema#label
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hnRNP A1
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gptkbp:interactsWith
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gptkb:SRSF1
gptkb:hnRNP_A2/B1
U2AF2
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gptkbp:locatedOnChromosome
|
12q13.13
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gptkbp:location
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gptkb:nucleus
gptkb:cytoplasm
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gptkbp:molecularWeight
|
~34 kDa
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gptkbp:organism
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gptkb:Homo_sapiens
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gptkbp:orthologIn
|
Mus musculus hnRNP A1
Rattus norvegicus hnRNP A1
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gptkbp:PDB
|
2LYV
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gptkbp:postTranslationalModification
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phosphorylation
methylation
sumoylation
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gptkbp:RefSeq
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NP_002127.1
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gptkbp:sequence
|
372 amino acids
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gptkbp:UniProtID
|
gptkb:P09651
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gptkbp:bfsParent
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gptkb:RRM_domain
gptkb:hnRNPA1
gptkb:hnRNP_proteins
gptkb:hnRNPs
gptkb:HNRNPA1
gptkb:NP_060551.2
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gptkbp:bfsLayer
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7
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